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SONAR Targetspace for CYCLOSPORINEZ-score WebGraph NB WebGraph
Targetspace hs 172 101
Targetspace hs pval0.0503144654088050.13092550790068
XgmmL File for compound download download
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:40
Sym Orf Description Function No All Z_score hyperg
YIP3 YNL044W Protein localized to COPII vesicles, proposed to be involved in ER to Golgi tran...   15 43   NAN
GDI1 YER136W GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by r... GDP dissociation inhibitor 14 25   0
GYP6 YJL044C GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved... GTPase activating protein (GAP) for Ypt6 14 13   0
MDR1 YGR100W Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31... GTPase activating protein (GAP) for Ypt6 12 13   0
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network; forms heterod...   9 14 -4.5173 0
YOP1 YPR028W Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpr...   7 17   0
YIP4 YGL198W Protein that interacts with Rab GTPases; computational analysis of large-scale p...   7 26   0
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps5... hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p 7 18   0.0001
YIP1 YGR172C Integral membrane protein required for the biogenesis of ER-derived COPII transp...   7 28   0.0001
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog...   7 45   NAN
MRS6 YOR370C Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is... rab geranylgeranyltransferase regulatory subunit 7 22   0
VAM6 YDL077C Vacuolar protein that plays a critical role in the tethering steps of vacuolar m...   7 39   0.0834
VPS33 YLR396C ATP-binding protein that is a subunit of the homotypic vacuole fusion and vacuol...   7 35   0
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleot...   6 10 -9.4689 0
MSB4 YOL112W GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, l...   6 11   0
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps5...   6 12   0
ACO1 YLR304C Aconitase, required for the tricarboxylic acid (TCA) cycle and also independentl... aconitase 6 28   0
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport GTPase activating protein (GAP) for Gsp1p 6 27   0
ZUO1 YGR285C Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the S... zuotin, Z-DNA binding protein (putative) 6 50   0
COG6 YNL041C Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cyt...   6 31   0
YIF1 YNL263C Integral membrane protein required for the fusion of ER-derived COPII transport ...   6 39   0
SGM1 YJR134C Protein of unknown function, required for wild-type growth rate on galactose and...   6 8   0.0256
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps5...   5 22   0
ERO1 YML130C Glycoprotein required for oxidative protein folding in the endoplasmic reticulum   4 11   0.0001
ERV41 YML067C Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involve...   4 15   0
BET3 YKR068C Hydrophilic protein that acts in conjunction with SNARE proteins in targeting an... transport protein particle (TRAPP) component 4 34   0
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into ... Ca2+ ATPase 4 22 1.3874 0.0777
TRS20 YBR254C One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-...   4 23   0
YEF3 YLR249W Translational elongation factor, stimulates the binding of aminoacyl-tRNA (AA-tR... Translation elongation factor 3 (EF-3) 4 94   0
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-asso... HSP70 family 4 85   0
APL1 YJR005W Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); i... beta-adaptin|clathrin associated protein complex large subunit 4 16   0
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly iden... chaperonin 4 144   0.1769
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mit... mammalian BAP37 and S. cerevisiae Phb1p homolog|prohibitin homolog 4 21   0.0001
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence...   3 36   0
SSN8 YNL025C Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphory... C-type cyclin|associates with the Ssn3p cyclin-dependent kinase 3 50   0.0025
MIR1 YJR077C Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; ...   3 29   0
FTH1 YBR207W Putative high affinity iron transporter involved in transport of intravacuolar s...   3 10   0
CBR1 YIL043C Microsomal cytochrome b reductase, not essential for viability; also detected in... cytochrome b reductase 3 27   0.1524
FLC2 YAL053W Putative protein of unknown function; green fluorescent protein (GFP)-fusion pro...   3 7   0.0315
FUS3 YBL016W Mitogen-activated protein kinase involved in mating pheromone response; activate... CDC28/cdc2 related protein kinase 3 129   0.0002

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