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SONAR Targetspace for CYCLOSPORINEZ-score WebGraph NB WebGraph
Targetspace hs 172 101
Targetspace hs pval0.0503144654088050.13092550790068
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:40
Sym Orf Description Function No⇑ All Z_score hyperg
  YDR107C     7 5   0.1632
  YDR266C     7 6   0
  YEL043W     7 4   0
  YMR010W     7 4   NAN
  YPR084W     7 4   0.0061
APL6 YGR261C Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline... clathrin assembly complex beta adaptin component (putative) 7 10   0
APM3 YBR288C Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in... clathrin associated protein complex medium subunit 7 15   0
EMP70 YLR083C Protein whose 24kDa cleavage product is found in endosome-enriched membrane frac...   7 7   0.011
ENT4 YLL038C Protein of unknown function, contains an N-terminal epsin-like domain   7 4   0.0046
ENT5 YDR153C Protein containing an N-terminal epsin-like domain involved in clathrin recruitm...   7 8   0.1234
GEF1 YJR040W Chloride channel localized to late- or post-Golgi vesicles, involved in iron met... transport protein involved in intracellular iron metabolism (putative) 7 10   0
IRS4 YKR019C Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentr...   7 10   0.0465
MAK31 YCR020C-A Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required...   7 5   0
MRL1 YPR079W Membrane protein with similarity to mammalian mannose-6-phosphate receptors, pos...   7 3   0.1577
NTO1 YPR031W Component of the histone acetyltransferase complex HAT complex component 7 10   0
NUP2 YLR335W Protein involved in nucleocytoplasmic transport, binds to either the nucleoplasm... nucleoporin 7 27   0
RET1 YOR207C Second-largest subunit of RNA polymerase III, which is responsible for the trans...   7 6   0.0656
RIS1 YOR191W Member of the SWI/SNF family of DNA-dependent ATPases, plays a role in antagoniz... SWI2/SNF2 DNA-dependent ATPase family member (putative) 7 14   0.1184
SBH1 YER087C-B Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involv... Sbh2p homolog 7 11   0
SEC20 YDR498C Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to... v-SNARE 7 9   0.0003
SEC28 YIL076W Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein tr... epsilon-COP coatomer subunit 7 19   0
STV1 YMR054W Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv... 110 kDa subunit; not in vacuole membrane|vacuolar H-ATPase 7 10   0
TEF4 YKL081W Translation elongation factor EF-1 gamma translation elongation factor EF-1gamma 7 15   0.0449
TLG1 YDR468C Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion ... tSNARE that affects a late Golgi compartment 7 6   0
  ETG9627     8 5   0
CDC50 YCR094W Endosomal protein that regulates cell polarity; similar to Ynr048wp and Lem3p   8 41   0
CMP2 YML057W Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calci... calcineurin subunit A 8 11   0.0001
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in v... GTPase activating protein (GAP) 8 67 0.6586 0
SYS1 YJL004C Integral membrane protein of the Golgi required for targeting of the Arf-like GT...   8 41   0
VPS30 YPL120W Protein that forms a membrane-associated complex with Apg14p that is essential f...   8 25   0.0526
RAV1 YJR033C Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of th...   9 30   0.0482
RER1 YCL001W Protein involved in retention of membrane proteins, including Sec12p, in the ER;...   9 73   0.1128
SEC21 YNL287W Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p... PEST sequence-containing protein|non-clathrin coat protein 9 26   0
DCR2 YLR361C Putative phosphoesterase that functions as a dosage-dependent positive regulator...   10 19   0
RPL16B YNL069C N-terminally acetylated protein component of the large (60S) ribosomal subunit, ... ribosomal protein L16B (L21B) (rp23) (YL15) 10 14   0.0038
VPS17 YOR132W Subunit of the membrane-associated retromer complex essential for endosome-to-Go...   10 21   0.0006
YPT1 YFL038C Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway... GTP-binding protein|ras homolog|similar to mammalian Rab1A protein 10 56   0.0143
MVP1 YMR004W Protein required for sorting proteins to the vacuole; overproduction of Mvp1p su...   11 16   0
PKR1 YMR123W Protein of unknown function; overproduction confers resistance to Pichia farinos...   11 32   0
SNX4 YJL036W Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golg...   14 12   0

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