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SONAR Targetspace for SIMVASTATINZ-score WebGraph NB WebGraph
Targetspace hs 98 102
Targetspace hs pval0.187203791469190.3801652892562
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:40
Sym Orf Description Function No All Z_score hyperg
VMA6 YLR447C Subunit D of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase ... vacuolar ATPase V0 domain subunit d (36 kDa)|vacuolar H(+) ATPase 36 kDa subunit (D subunit of VO sector) 4 32   0.0046
STE24 YJR117W Highly conserved zinc metalloprotease that functions in two steps of a-factor ma... zinc metallo-protease 3 7   0.0796
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the dire... pyruvate dehydrogenase alpha subunit (E1 alpha) 3 23   0.2035
HXK2 YGL253W Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol;... hexokinase II (PII) (also called hexokinase B) 3 22 -9.4755 0.0942
TIF3 YPR163C Translation initiation factor eIF-4B, has RNA annealing activity; contains an RN... translation initiation factor eIF-4B 3 17 0.2922 0
RBG1 YAL036C Member of the DRG family of GTP-binding proteins; interacts with translating rib...   3 24   0
TKL1 YPR074C Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate an... transketolase 1 3 18   0.0504
VMA13 YPR036W Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-... vacuolar H(+) ATPase V1 sector 54 kDa subunit 3 28   0.164
VPH1 YOR270C Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph... V0 sector subunit|essential for vacuolar acidification and vacuolar H-ATPase activity|vacuolar ATPase V0 domain subunit a (100 kDa)|vacuolar H-ATPase 3 43 -7.7590 0.1963
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex, which is involved in regulati...   3 57 -12.6479 0
CHS3 YBR023C Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to c... chitin synthase 3 3 19 -7.3405 0
FAS2 YPL231W Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-ch... fatty acid synthase alpha subunit 3 27   0
SEC4 YFL005W Secretory vesicle-associated Rab GTPase essential for exocytosis; associates wit... ras homolog|small GTP binding protein 2 39   0.0023
  YPL009C     2 12   0
SFL1 YOR140W Transcription repressor involved in regulation of flocculation-related genes, in... transcription factor 2 16   0
NTO1 YPR031W Component of the histone acetyltransferase complex HAT complex component 2 10   0.0043
ULP1 YPL020C Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjug... Smt3-specific protease 2 27   0.1789
SCD6 YPR129W Protein containing an Lsm domain, may bind RNA and have a role in RNA processing...   2 43   0.0138
UFD4 YKL010C Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits ... ubiquitin ligase e3 2 33   0.0201
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog...   2 35   0.0014
  YPR045C     2 15   0.0138
PUS1 YPL212C tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36... tRNA pseudouridine synthase 2 10   0
DOP1 YDR141C Protein of unknown function, essential for viability, involved in establishing c...   2 16   0.1881
NAS2 YIL007C Protein with similarity to the p27 subunit of mammalian proteasome modulator; no...   2 24   0
  YAR009C     2 9   0
YIP3 YNL044W Protein localized to COPII vesicles, proposed to be involved in ER to Golgi tran...   2 43   0
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network; forms heterod...   2 14 1.2926 0
RPN7 YPR108W Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to anoth... proteasome regulatory particle subunit 2 59   0
TPS1 YBR126C Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which sy... trehalose-6-phosphate synthase/phosphatase complex 56 kDa synthase subunit 2 45   0.1689
ARX1 YDR101C Protein associated with the ribosomal export complex   2 102 2.2227 0.0657
PGI1 YBR196C Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glu... glucose-6-phosphate isomerase|phosphoglucose isomerase 2 21   0
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid   2 45   0.0014
WRS1 YOL097C Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA tryptophan-tRNA ligase 2 10   0
TRP2 YER090W Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, fo... anthranilate synthase component I 2 16   0
YPT32 YGL210W GTPase of the Ypt/Rab family, very similar to Ypt31p; involved in the exocytic p... GTPase|YPT31 homolog|ras homolog 2 26   0.1242
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermenta... pyruvate decarboxylase 2 44   0.0157
SAC1 YKL212W Lipid phosphoinositide phosphatase of the ER and Golgi, involved in protein traf... phosphoinositide phosphatase 2 21   0
RGT1 YKL038W Glucose-responsive transcription factor that regulates expression of several glu... transcriptional activator|transcriptional repressor 2 18   0
CRM1 YGR218W Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits ... chromosome region maintenance protein 2 111   0
TOP1 YOL006C Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleavin... topoisomerase I 2 47 -0.7833 0.0252

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