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SONAR Targetspace for DONEPEZIL HYDROCHLORIDEZ-score WebGraph NB WebGraph
Targetspace hs 247 122
Targetspace hs pval0.0245398773006130.36885245901639
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:38
Sym Orf Description Function No All Z_score hyperg
NHX1 YDR456W Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; req... Na+/H+ exchanger 10 61   0
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxy...   9 31   0.0004
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenot...   7 59   0.0229
PKR1 YMR123W Protein of unknown function; overproduction confers resistance to Pichia farinos...   7 32   0
VPS17 YOR132W Subunit of the membrane-associated retromer complex essential for endosome-to-Go...   7 21   0.0218
SKY1 YMR216C SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabo...   6 97   0.0001
SNX4 YJL036W Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golg...   6 12   0.0049
DCR2 YLR361C Putative phosphoesterase that functions as a dosage-dependent positive regulator...   6 19   0
GOS1 YHL031C v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GO...   5 56   0
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision... endonuclease III DNA base excision repair N-glycosylase 5 23   0
MID1 YNL291C N-glycosylated integral membrane protein of the ER membrane and plasma membrane,... N-glycosylated integral plasma membrane protein 5 28   0.1657
MMS1 YPR164W Protein likely involved in protection against replication-dependent DNA damage; ...   5 83   0.1099
VPS30 YPL120W Protein that forms a membrane-associated complex with Apg14p that is essential f...   5 25   0.1879
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex under low-sa...   5 29   0
IMH1 YLR309C Protein involved in vesicular transport, mediates transport between an endosomal...   5 4   0.0002
MGA2 YIR033W ER membrane protein involved, with its homolog Spt23p, in regulation of OLE1 tra...   5 146   0
YPT1 YFL038C Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway... GTP-binding protein|ras homolog|similar to mammalian Rab1A protein 5 56   0.0001
ERV14 YGL054C Protein localized to COPII-coated vesicles, involved in vesicle formation and in... 14 kDa protein found on ER-derived vesicles 5 76   0
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in v... GTPase activating protein (GAP) 5 67 0.9283 0
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in tr... v-SNARE 5 14   0.1408
VPS29 YHR012W Endosomal protein that is a subunit of the membrane-associated retromer complex ...   5 52   0.0601
PEP8 YJL053W Vacuolar protein sorting protein that forms part of the multimeric membrane-asso... vacuolar protein similar to mouse gene H<beta>58 5 27   0
RAV1 YJR033C Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of th...   5 30   0.1876
MVP1 YMR004W Protein required for sorting proteins to the vacuole; overproduction of Mvp1p su...   5 16   0
RAV2 YDR202C Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 dom...   5 7   0.1387
EXO1 YOR033C 5--3- exonuclease and flap-endonuclease involved in recombination, double-strand... exonuclease 5 63   0
CDC50 YCR094W Endosomal protein that regulates cell polarity; similar to Ynr048wp and Lem3p   4 41   0
SLY1 YDR189W Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM... t-SNARE-interacting protein that functions in ER-to-Golgi traffic 4 38   0.2027
TOP2 YNL088W Essential type II topoisomerase, relieves torsional strain in DNA by cleaving an... topoisomerase II 4 15   0.0104
RPL22A YLR061W Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22B... ribosomal protein L22A (L1c) (rp4) (YL31) 4 4   0
FUN30 YAL019W Protein whose overexpression affects chromosome stability, potential Cdc28p subs...   4 27   0
HPR1 YDR138W Subunit of THO/TREX complexes that couple transcription elongation with mitotic ...   4 75   0.0033
TLG2 YOL018C Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fus... tSNARE that affects a late Golgi compartment 4 128   0
STV1 YMR054W Subunit of vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv... 110 kDa subunit; not in vacuole membrane|vacuolar H-ATPase 4 10   0
SEC27 YGL137W Essential beta--coat protein of the COPI coatomer, involved in ER-to-Golgi and G... yeast coatomer beta--subunit 4 14   0
  YPR084W     4 4   0.0003
DOA4 YDR069C Ubiquitin hydrolase, required for recycling ubiquitin from proteasome-bound ubiq... ubiquitin isopeptidase 4 75 -2.5553 0.0104
  YJL123C     4 30   0.0152

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