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SONAR Targetspace for DONEPEZIL HYDROCHLORIDEZ-score WebGraph NB WebGraph
Targetspace hs 247 122
Targetspace hs pval0.0245398773006130.36885245901639
XgmmL File for compound download download
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:40
Sym Orf Description⇑ Function No All Z_score hyperg
  YFR011C     2 3   0
  YLR021W     2 15   0.0711
  YPL144W     2 23   0.2836
PRE2 YPR103W 20S proteasome beta-type subunit, responsible for the chymotryptic activity of t... proteasome subunit 2 63   0.1178
ACO1 YLR304C Aconitase, required for the tricarboxylic acid (TCA) cycle and also independentl... aconitase 5 28   0
ARP10 YDR106W Actin-related protein   2 9   0
PUP3 YER094C Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; h... 20S proteasome subunit beta3_sc 2 35   0
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex, which is involved in regulati...   3 57 -2.4851 0
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps5... hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p 3 18   0.0632
JNM1 YMR294W Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p...   3 19   0.0053
MDR1 YGR100W Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31... GTPase activating protein (GAP) for Ypt6 6 13   0
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog...   3 45   0
CAF40 YNL288W Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling...   2 39   0.069
GDI1 YER136W GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by r... GDP dissociation inhibitor 6 25   0
GYP6 YJL044C GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved... GTPase activating protein (GAP) for Ypt6 6 13   0
MSB4 YOL112W GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, l...   3 11   0
YIP1 YGR172C Integral membrane protein required for the biogenesis of ER-derived COPII transp...   3 28   0.0657
YIF1 YNL263C Integral membrane protein required for the fusion of ER-derived COPII transport ...   4 39   0
YOP1 YPR028W Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpr...   3 17   0
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network; forms heterod...   5 14 -2.4532 0
YIP3 YNL044W Protein localized to COPII vesicles, proposed to be involved in ER to Golgi tran...   6 43   NAN
SGM1 YJR134C Protein of unknown function, required for wild-type growth rate on galactose and...   3 8   0.2273
XRS2 YDR369C Protein required for DNA repair; component of the Mre11 complex, which is involv... DNA repair protein 2 20   0
YIP4 YGL198W Protein that interacts with Rab GTPases; computational analysis of large-scale p...   3 26   0
MRS6 YOR370C Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is... rab geranylgeranyltransferase regulatory subunit 3 22   0.0025
RIM1 YCR028C-A Single-stranded DNA-binding protein essential for mitochondrial genome maintenan... DNA binding protein 2 31   0
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II tra... TFIID subunit 3 82   0.0018
MNN9 YPL050C Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn1... required for complex glycosylation 4 20   0
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, ... mannosyltransferase complex component 4 21   0
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleot...   3 10 -9.7468 0
RFA2 YNL312W Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserv... 29% identical to the human p34 subunit of RF-A|replication factor RF-A subunit 2 2 37   0.1092
RFA3 YJL173C Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserv... replication factor-A subunit 3 2 37   0
NOT5 YPR072W Subunit of the CCR4-NOT complex, which is a global transcriptional regulator wit... NOT complex member, a global negative regulator of transcription 2 41   0.0046
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; ...   3 22   0.0001
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA ... DNA polymerase delta binding protein 4 73   0.131
YEF3 YLR249W Translational elongation factor, stimulates the binding of aminoacyl-tRNA (AA-tR... Translation elongation factor 3 (EF-3) 4 94   0
BET1 YIL004C Type II membrane protein required for vesicular transport between the endoplasmi...   2 40   0.1146
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in tr... v-SNARE 2 55   0.0218
SED5 YLR026C cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and t... syntaxin family 2 83   0.0224
UFE1 YOR075W t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane... t-SNARE (ER) 2 19   0.0575

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