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SONAR Targetspace for QUINACRINE HYDROCHLORIDEZ-score WebGraph NB WebGraph
Targetspace hs 85 419
Targetspace hs pval0.658940397350990.041580041580042
XgmmL File for compound download download
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Dynamic Data Scan For Putative Targets (genetic,physical,all)
Prediction Returned Rows:40
Sym Orf Description Function No All Z_score hyperg⇓
SEC6 YIL068C Essential 88kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec1... exocyst complex component 5 43   0.1887
DER1 YBR201W Endoplasmic reticulum membrane protein, required for ER-associated protein degra...   4 20   0.1431
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; ... vesicle coat component 4 11   0.1347
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation via three independen... MAP kinase 4 81 -7.1413 0.0885
RPB4 YJL140W RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p;... RNA polymerase II fourth largest subunit 5 36   0.0403
SIN4 YNL236W Subunit of the Mediator complex; interacts with the RNA polymerase II holoenzyme... RNA polymerase II holoenzyme/mediator subunit 3 59   0.0297
HRD1 YOL013C Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradati...   5 61   0.0283
ERV29 YGR284C Protein localized to COPII-coated vesicles, involved in vesicle formation and in... ER-Golgi transport vesicle protein 4 24   0.0185
SMC6 YLR383W Protein involved in structural maintenance of chromosomes; essential subunit of ...   3 31   0.0105
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodim... ATP dependent DNA ligase 3 15   0.0081
ERD2 YBL040C Integral membrane protein that binds to the HDEL motif in proteins destined for ... HDEL receptor 4 8   0.0067
GTR1 YML121W Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cyc... small GTPase (putative) 5 57   0.0011
UFE1 YOR075W t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane... t-SNARE (ER) 4 18   0.0007
SLM4 YBR077C Component of the EGO complex, which is involved in the regulation of microautoph...   3 10   0.0001
  YBR138C     4 1   0
  YKL206C     4 3   0
ADE3 YGR204W Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in singl... C1-tetrahydrofolate synthase 4 10   0
BMH2 YDR099W 14-3-3 protein, minor isoform; binds proteins and DNA, involved in regulation of... member of conserved eukaryotic 14-3-3 gene family 4 29   0
COS8 YHL048W Nuclear membrane protein, member of the DUP380 subfamily of conserved, often sub...   4 4   0
CYS3 YAL012W Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the tr... cystathionine gamma-lyase 4 61   0
GCN4 YEL009C Transcriptional activator of amino acid biosynthetic genes in response to amino ... transcriptional activator of amino acid biosynthetic genes 4 40   0
GCV1 YDR019C T subunit of the mitochondrial glycine decarboxylase complex, required for the c... glycine decarboxylase complex T subunit 3 8   0
GTR2 YGR163W Cytoplasmic GTP binding protein, negative regulator of the Ran/Tc4 GTPase cycle ... similar to Gtr1|small GTPase (putative) 3 16   0
KAR2 YJL034W ATPase involved in protein import into the ER, also acts as a chaperone to media... HSP70 family|mammalian BiP (GRP78 or HSPA5) homolog 4 20   0
LST7 YGR057C Protein possibly involved in a post-Golgi secretory pathway; required for the tr...   3 5   0
MKC7 YDR144C GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares f... aspartyl protease|related to Yap3p|yapsin 2 4 12   0
PDI1 YCL043C Protein disulfide isomerase, multifunctional protein resident in the endoplasmic... protein disulfide isomerase 4 123   0
RFA1 YAR007C Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserv... RF-A|heterotrimeric RPA (RF-A) single-stranded DNA binding protein 69 kDa subunit 3 43   0
SAR1 YPL218W GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicl... ARF family|GTP-binding protein 4 14   0
SCH9 YHR205W Protein kinase that regulates signal transduction activity and G1 progression, c... cAMP-dependent protein kinase homolog|suppressor of cdc25ts 4 59   0
SEC12 YNR026C Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein... guanine nucleotide exchange factor for Sar1p 8 27   0
SEC13 YLR208W Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (S... nuclear pore complex subunit|protein involved in release of transport vesicles from the ER 7 25   0
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding and autopha... vesicle coat component 8 14   0
SEC17 YBL050W Peripheral membrane protein required for vesicular transport between ER and Golg...   3 11   0
SEC31 YDL195W Essential phosphoprotein component (p150) of the COPII coat of secretory pathway... COPII coat of secretory pathway vesicles component (p150) 4 9   0
SER1 YOR184W 3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from ... phosphoserine transaminase 4 12 -12.9171 0
SER2 YGR208W Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine an... phosphoserine phosphatase 5 15   0
SIL1 YOL031C Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chap... Nucleotide exchange factor 4 52   0
SMC3 YJL074C Subunit of the multiprotein cohesin complex required for sister chromatid cohesi... SMC chromosomal ATPase family member 3 13   0
ZAP1 YJL056C Zinc-regulated transcription factor, binds to zinc-responsive promoter elements ...   4 30   0

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