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Compound InformationSONAR Target prediction
Name:

COLCHICEINE

Unique Identifier:SPE01800067
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C21H23NO6
Molecular Weight:362.228 g/mol
X log p:9.362  (online calculus)
Lipinksi Failures1
TPSA61.83
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:7
Rotatable Bond Count:5
Canonical Smiles:COc1cc2CCC(NC(C)=O)C3=CC(=O)C(O)=CC=C3c2c(OC)c1OC
Source:antimitotic ex Colchicum autumnale
Reference:Col Czech Chem Commun 19: 805 (1954)
Therapeutics:antimitotic

Found: 58 active | as graph: single | with analogs [1] << Back 1 2 3 4 5 6 7 8 9 10  Next >> [58]
Species: 4932
Condition: BCK1
Replicates: 2
Raw OD Value: r im 0.5189±0.000636396
Normalized OD Score: sc h 0.7224±0.000279541
Z-Score: -5.4259±0.101413
p-Value: 0.0000000622228
Z-Factor: 0.784713
Fitness Defect: 16.5925
Bioactivity Statement: Active
Experimental Conditions
Library:Spectrum
Plate Number and Position:13|B8
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:25.80 Celcius
Date:2006-03-24 YYYY-MM-DD
Plate CH Control (+):0.03825±0.00111
Plate DMSO Control (-):0.6919±0.01335
Plate Z-Factor:0.9311
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DBLink | Rows returned: 3
10156
234105
6993782

internal high similarity DBLink | Rows returned: 3
BTB 12749 0.9440
LOPAC 00810 0.9440
SPE01500205 0.9440

active | Cluster 2172 | Additional Members: 11 | Rows returned: 2
Prest353 0.493506493506494
Prest875 0.386363636363636

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