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Compound InformationSONAR Target prediction
Name:

COLCHICEINE

Unique Identifier:SPE01800067
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C21H23NO6
Molecular Weight:362.228 g/mol
X log p:9.362  (online calculus)
Lipinksi Failures1
TPSA61.83
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:7
Rotatable Bond Count:5
Canonical Smiles:COc1cc2CCC(NC(C)=O)C3=CC(=O)C(O)=CC=C3c2c(OC)c1OC
Source:antimitotic ex Colchicum autumnale
Reference:Col Czech Chem Commun 19: 805 (1954)
Therapeutics:antimitotic

Found: 58 active | as graph: single | with analogs 1 2 3 4 5 6 7 8 9 10  Next >> [58]
Species: 4932
Condition: ARP1
Replicates: 2
Raw OD Value: r im 0.5674±0.0185969
Normalized OD Score: sc h 0.7644±0.0281396
Z-Score: -11.8316±0.510481
p-Value: 9.26942e-31
Z-Factor: 0.50093
Fitness Defect: 69.1534
Bioactivity Statement: Active
Experimental Conditions
Library:Spectrum
Plate Number and Position:13|B8
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:27.10 Celcius
Date:2006-03-23 YYYY-MM-DD
Plate CH Control (+):0.040125±0.00188
Plate DMSO Control (-):0.728±0.00765
Plate Z-Factor:0.9617
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DBLink | Rows returned: 3
10156
234105
6993782

internal high similarity DBLink | Rows returned: 3
BTB 12749 0.9440
LOPAC 00810 0.9440
SPE01500205 0.9440

active | Cluster 2172 | Additional Members: 11 | Rows returned: 2
Prest353 0.493506493506494
Prest875 0.386363636363636

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