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Compound InformationSONAR Target prediction
Name:

COLFORSIN

Unique Identifier:SPE01503804
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:
Molecular Weight:376.231 g/mol
X log p:-0.972  (online calculus)
Lipinksi Failures0
TPSA52.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:7
Rotatable Bond Count:3
Canonical Smiles:CC(=O)OC1C(O)C2C(C)(C)CCC(O)C2(C)C2(O)C(=O)CC(C)(OC12C)C=C
Class:diterpene
Source:Coleus forskohlii; HL-362; L-75-1362B
Reference:J Biol Chem 258:2960 (1983); J Med Chem 26:436, 486 (1983); TIPS 10:442 (1989)
Therapeutics:adenylate cyclase activator, antiglaucoma, hypotensive, vasodilator
Generic_name:FORSKOLIN
Chemical_iupac_name:FORSKOLIN
Drug_type:Experimental
Drugbank_id:EXPT01467
Drug_category:Adenylyl Cyclase inhibitor
Organisms_affected:-1

Found: 205 nonactive as graph: single | with analogs [1] << Back 1 2 3 4 5 6 7 8 9 10  Next >> [205]
Species: 4932
Condition: NPR1
Replicates: 2
Raw OD Value: r im 0.9563±0.0154149
Normalized OD Score: sc h 0.9333±0.00249025
Z-Score: -0.7263±0.39765
p-Value: 0.484978
Z-Factor: -0.354739
Fitness Defect: 0.7237
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Spectrum_ED
Plate Number and Position:1|B10
Drug Concentration:50.00 nM
OD Absorbance:595 nm
Robot Temperature:30.00 Celcius
Date:2012-09-18 YYYY-MM-DD
Plate CH Control (+):0.0081±0.00469
Plate DMSO Control (-):1.0006249999999999±0.02736
Plate Z-Factor:0.9248
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DBLink | Rows returned: 112 Next >> 
3413
47936
337799
396205
451120
3537287

internal high similarity DBLink | Rows returned: 1
LOPAC 00432 1.0000

active | Cluster 2047 | Additional Members: 3 | Rows returned: 0

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