Compound Information | SONAR Target prediction | Name: | LANOSTEROL | Unique Identifier: | SPE00240470 | MolClass: | Checkout models in ver1.5 and ver1.0 | Molecular Formula: | C30H50O | Molecular Weight: | 376.32 g/mol | X log p: | 2.412 (online calculus) | Lipinksi Failures | 0 | TPSA | 0 | Hydrogen Bond Donor Count: | 0 | Hydrogen Bond Acceptors Count: | 1 | Rotatable Bond Count: | 4 | Canonical Smiles: | CC(CCC=C(C)C)C1CCC2(C)C3CCC4C(C)(C)C(O)CCC4(C)C=3CCC12C | Source: | ex wool fat of sheep | Generic_name: | LANOSTEROL | Chemical_iupac_name: | LANOSTEROL | Drug_type: | Experimental | Kegg_compound_id: | C01724 | Drugbank_id: | EXPT02002 | Logp: | 7.63 | Cas_registry_number: | 79-63-0 | Drug_category: | Lanosterol Synthase inhibitor | Organisms_affected: | -1 |
Species: |
4932 |
Condition: |
YPT6 |
Replicates: |
2 |
Raw OD Value: r im |
0.4833±0.019304 |
Normalized OD Score: sc h |
0.7634±0.0216334 |
Z-Score: |
-7.9349±0.335558 |
p-Value: |
0.0000000000000070806 |
Z-Factor: |
0.0882711 |
Fitness Defect: |
32.5814 |
Bioactivity Statement: |
Active |
Experimental Conditions | | Library: | Spectrum | Plate Number and Position: | 4|G6 | Drug Concentration: | 50.00 nM | OD Absorbance: | 600 nm | Robot Temperature: | 21.90 Celcius | Date: | 2006-02-22 YYYY-MM-DD | Plate CH Control (+): | 0.041425000000000003±0.00104 | Plate DMSO Control (-): | 0.6384000000000001±0.03634 | Plate Z-Factor: | 0.9350 |
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2-[(1R,8S)-1,8-dimethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl]propan-2-ol |
5319548 |
17-[(E)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopen ta[a]phenanthren-3-ol |
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(3S,10R,13S,17R)-4,10,13-trimethyl-17-(6-methyl-5-methylidene-heptan-2-yl)-2,3,4,5,6,9,11,12,14,15,16,17 -dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
5319640 |
(3S,10S,13R)-10,13,14-trimethyl-17-(6-methyl-5-methylidene-heptan-2-yl)-1,2,3,4,5,6,7,8,12,15,16,17-dode cahydrocyclopenta[a]phenanthren-3-ol |
5319641 |
(3S,10S,13R)-17-(5,6-dimethylheptan-2-yl)-10,13,14-trimethyl-1,2,3,4,5,6,7,8,12,15,16,17-dodecahydrocycl openta[a]phenanthren-3-ol |
5319652 |
17-(5-ethyl-6-methyl-hept-5-en-2-yl)-4,10,13-trimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cycl openta[a]phenanthren-3-ol |
internal high similarity DBLink | Rows returned: 11 | 1 2 Next >> |
active | Cluster 1278 | Additional Members: 6 | Rows returned: 2 | |
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