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Compound InformationSONAR Target prediction
Name:

Colchicine

Unique Identifier:LOPAC 00810
MolClass: Checkout models in ver1.5 and ver1.0
Molecular Formula:C22H25NO6
Molecular Weight:374.239 g/mol
X log p:9.286  (online calculus)
Lipinksi Failures1
TPSA71.06
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptors Count:7
Rotatable Bond Count:6
Canonical Smiles:COC1=CC=C2C(=CC1=O)C(CCc1cc(OC)c(OC)c(OC)c12)NC(C)=O
Class:Cytoskeleton and ECM
Action:Inhibitor
Selectivity:Tubulin

Found: 24 nonactive as graph: single | with analogs [1] << Back 1 2 3 4 5 6 7 8 9 10  Next >> [24]
Species: 4932
Condition: CIN2
Replicates: 2
Raw OD Value: r im 0.8416±0.017112
Normalized OD Score: sc h 1.0033±0.00845336
Z-Score: 0.2202±0.618804
p-Value: 0.669312
Z-Factor: -157.704
Fitness Defect: 0.4015
Bioactivity Statement: Nonactive
Experimental Conditions
Library:Lopac
Plate Number and Position:4|G11
Drug Concentration:50.00 nM
OD Absorbance:600 nm
Robot Temperature:26.90 Celcius
Date:2005-12-07 YYYY-MM-DD
Plate CH Control (+):0.039025000000000004±0.00114
Plate DMSO Control (-):0.8283499999999999±0.01004
Plate Z-Factor:0.9451
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DBLink | Rows returned: 71 2 Next >> 
2833
6167
23758
53278
450692
537229

internal high similarity DBLink | Rows returned: 3
SPE01800067 0.9440
BTB 12749 1.0000
SPE01500205 1.0000

active | Cluster 2172 | Additional Members: 11 | Rows returned: 3
Prest353 0.493506493506494
Prest875 0.386363636363636
SPE01800067 0.217391304347826

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