CHEMGRID MOLECULE CARD
3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid in ChemGrid: 50 screened assays, 7 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SS 00042
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SS 00042
- Molecular formula
- C18H15NO3
- InChIKey
- OFPXSFXSNFPTHF-UHFFFAOYSA-N
- Libraries
- Maybridge1000
- Other recorded names
- Oxaprozin
Stored SMILES
OC(=O)CCc1oc(c2ccccc2)c(n1)c1ccccc1Matched external records: PubChem 4614
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
50 measurements across 50 distinct library–species–strain assays; 7 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| kre1 | Maybridge1000 | 4932 | -5.16 |
| pac10 | Maybridge1000 | 4932 | -4.94 |
| shm2 | Maybridge1000 | 4932 | -4.46 |
| sap30 | Maybridge1000 | 4932 | -4.33 |
| hoc1 | Maybridge1000 | 4932 | -4.16 |
| esc1 | Maybridge1000 | 4932 | -4.05 |
| rot2 | Maybridge1000 | 4932 | -4.03 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL | No stored yeast mapping |
| C5 · Complement C5 | ChEMBL | No stored yeast mapping |
| DRD2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD3 · D(3) dopamine receptor | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| HRH1 · Histamine H1 receptor | ChEMBL | PRP22 YER013W (ortholog_one2one) |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL | No stored yeast mapping |
| PTGS1 · Prostaglandin G/H synthase 1 | ChEMBL | No stored yeast mapping |
| PTGS2 · Prostaglandin G/H synthase 2 | ChEMBL | No stored yeast mapping |
| SHMT2 · Serine hydroxymethyltransferase, mitochondrial | ChEMBL | SHM2 YLR058C (ortholog_one2many) |
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| C5 · Complement C5 | ChEMBL analogue | No stored yeast mapping |
| DRD2 · D(2) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| DRD3 · D(3) dopamine receptor | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| HRH1 · Histamine H1 receptor | ChEMBL analogue | PRP22 YER013W (ortholog_one2one) |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL analogue | No stored yeast mapping |
| PTGS1 · Prostaglandin G/H synthase 1 | ChEMBL analogue | No stored yeast mapping |
| PTGS2 · Prostaglandin G/H synthase 2 | ChEMBL analogue | No stored yeast mapping |
| SHMT2 · Serine hydroxymethyltransferase, mitochondrial | ChEMBL analogue | SHM2 YLR058C (ortholog_one2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.