CHEMGRID MOLECULE CARD
BIOCHANIN A
BIOCHANIN A in ChemGrid: 114 screened assays, 109 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE10100003
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE10100003
- Molecular formula
- C16H12O5
- CAS registry number
- 491-80-5
- InChIKey
- WUADCCWRTIWANL-UHFFFAOYSA-N
- Libraries
- Spectrum, Spectrum_ED
- Other recorded names
- Biochanin A
Stored SMILES
COc1ccc(cc1)C1=COc2cc(O)cc(O)c2C1=OMatched external records: PubChem 5280373
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
114 measurements across 114 distinct library–species–strain assays; 109 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| BEM2 | Spectrum | 4932 | -43.33 |
| CIN8 | Spectrum | 4932 | -43.28 |
| mad1 | Spectrum | 4932 | -42.51 |
| CIN2 | Spectrum | 4932 | -39.99 |
| clb2 | Spectrum | 4932 | -39.91 |
| BY4743 | Spectrum_ED | 4932 | -39.87 |
| rvs167 | Spectrum | 4932 | -39.73 |
| MT2481-pdr1pdr3-2nd | Spectrum | 4932 | -39.16 |
| CNB1 | Spectrum | 4932 | -38.44 |
| mck1 | Spectrum | 4932 | -37.70 |
| pex11 | Spectrum | 4932 | -37.32 |
| tif3 | Spectrum | 4932 | -37.28 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CA12 · Carbonic anhydrase 12 | ChEMBL | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL | No stored yeast mapping |
| CBR1 · Carbonyl reductase [NADPH] 1 | ChEMBL | YIR035C (ortholog_many2many); YIR036C (ortholog_many2many) |
| CYP19A1 · Aromatase | ChEMBL | No stored yeast mapping |
| CYP1B1 · Cytochrome P450 1B1 | ChEMBL | No stored yeast mapping |
| MAOA · Monoamine oxidase | ChEMBL | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL | NCR1 YPL006W (ortholog_one2one) |
| RAB9A · Ras-related protein Rab-9A | ChEMBL | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL | No stored yeast mapping |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL analogue | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL analogue | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ALDH2 · Aldehyde dehydrogenase, mitochondrial | ChEMBL analogue | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL analogue | No stored yeast mapping |
| AOX1 · Aldehyde oxidase | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| BCL2 · Apoptosis regulator Bcl-2 | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| BRCA1 · Breast cancer type 1 susceptibility protein | ChEMBL analogue | No stored yeast mapping |
| CA12 · Carbonic anhydrase 12 | ChEMBL analogue | No stored yeast mapping |
| CA4 · Carbonic anhydrase 4 | ChEMBL analogue | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL analogue | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL analogue | No stored yeast mapping |
| CYP2D6 · Cytochrome P450 2D6 | ChEMBL analogue | No stored yeast mapping |
| DPP4 · Dipeptidyl peptidase 4 | ChEMBL analogue | DAP2 YHR028C (ortholog_one2one) |
| EGFR · Epidermal growth factor receptor | ChEMBL analogue | No stored yeast mapping |
| ESR1 · Estrogen receptor | ChEMBL analogue | No stored yeast mapping |
| ESR2 · Estrogen receptor beta | ChEMBL analogue | No stored yeast mapping |
First 30 of 72 target records; open the interactive profile for further evidence.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete BIOCHANIN A research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.