CHEMGRID MOLECULE CARD
METOLAZONE
METOLAZONE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE02300325
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE02300325
- Molecular formula
- C16ClH16N3O3S
- CAS registry number
- 17560-51-9
- InChIKey
- AQCHWTWZEMGIFD-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Metolazone
Stored SMILES
CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=OMatched external records: PubChem 4170
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALDH1A1 · Aldehyde dehydrogenase 1A1 | ChEMBL | ALD5 YER073W (ortholog_many2many); ALD3 YMR169C (ortholog_many2many); ALD2 YMR170C (ortholog_many2many); ALD4 YOR374W (ortholog_many2many); ALD6 YPL061W (ortholog_many2many) |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| CA2 · Carbonic anhydrase 2 | ChEMBL | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL | No stored yeast mapping |
| FEN1 · Flap endonuclease 1 | ChEMBL | RAD27 YKL113C (ortholog_one2one) |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| NFKB1 · Nuclear factor NF-kappa-B p105 subunit | ChEMBL | No stored yeast mapping |
| SMPD1 · Sphingomyelin phosphodiesterase | ChEMBL | PPN1 YDR452W (ortholog_one2many) |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete METOLAZONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.