CHEMGRID MOLECULE CARD
MEXAMINE
MEXAMINE in ChemGrid: 192 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE02300296
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE02300296
- Molecular formula
- C11ClH15N2O
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- 5-Methoxytryptamine
Stored SMILES
Cl.COc1ccc2ncc(CCN)c2c1Matched external records: PubChem 1833
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Serotonin 1 (5-HT1) receptor | ChEMBL | No stored yeast mapping |
| Serotonin 2 (5-HT2) receptor | ChEMBL | No stored yeast mapping |
| HTR1A · 5-hydroxytryptamine receptor 1A [CHEMBL214] | ChEMBL | No stored yeast mapping |
| Htr1a · 5-hydroxytryptamine receptor 1A [CHEMBL273] | ChEMBL | No stored yeast mapping |
| HTR1B · 5-hydroxytryptamine receptor 1B [CHEMBL1898] | ChEMBL | No stored yeast mapping |
| Htr1b · 5-hydroxytryptamine receptor 1B [CHEMBL3459] | ChEMBL | No stored yeast mapping |
| HTR1D · 5-hydroxytryptamine receptor 1D | ChEMBL | No stored yeast mapping |
| HTR2A · 5-hydroxytryptamine receptor 2A | ChEMBL | No stored yeast mapping |
| HTR4 · 5-hydroxytryptamine receptor 4 | ChEMBL | No stored yeast mapping |
| HTR6 · 5-hydroxytryptamine receptor 6 | ChEMBL | No stored yeast mapping |
| HTR7 · 5-hydroxytryptamine receptor 7 [CHEMBL3155] | ChEMBL | No stored yeast mapping |
| Htr7 · 5-hydroxytryptamine receptor 7 [CHEMBL3223] | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete MEXAMINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.