CHEMGRID MOLECULE CARD
GLYBURIDE
GLYBURIDE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE02300229
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE02300229
- Molecular formula
- C23ClH28N3O5S
- CAS registry number
- 10238-21-8
- InChIKey
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Glibenclamide
Stored SMILES
COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1Matched external records: PubChem 3488
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Abcb11 · Bile salt export pump | ChEMBL | MDL1 YLR188W (ortholog_many2many); MDL2 YPL270W (ortholog_many2many) |
| CISD1 · CDGSH iron-sulfur domain-containing protein 1 | ChEMBL | No stored yeast mapping |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| KCNJ11 · Sulfonylurea receptor 1, Kir6.2 | ChEMBL | No stored yeast mapping |
| KCNJ11 · Sulfonylurea receptor 2, Kir6.2 | ChEMBL | No stored yeast mapping |
| PPARG · Peroxisome proliferator-activated receptor gamma | ChEMBL | No stored yeast mapping |
| Slc22a6 · Solute carrier family 22 member 6 | ChEMBL | PHO84 YML123C (ortholog_one2many) |
| TSHR · Thyrotropin receptor | ChEMBL | No stored yeast mapping |
| Abcb11 · Bile salt export pump | ChEMBL analogue | MDL1 YLR188W (ortholog_many2many); MDL2 YPL270W (ortholog_many2many) |
| CISD1 · CDGSH iron-sulfur domain-containing protein 1 | ChEMBL analogue | No stored yeast mapping |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL analogue | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL analogue | No stored yeast mapping |
| KCNJ11 · Sulfonylurea receptor 1, Kir6.2 | ChEMBL analogue | No stored yeast mapping |
| KCNJ11 · Sulfonylurea receptor 2, Kir6.2 | ChEMBL analogue | No stored yeast mapping |
| PPARG · Peroxisome proliferator-activated receptor gamma | ChEMBL analogue | No stored yeast mapping |
| Slc22a6 · Solute carrier family 22 member 6 | ChEMBL analogue | PHO84 YML123C (ortholog_one2many) |
| TSHR · Thyrotropin receptor | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete GLYBURIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.