CHEMGRID MOLECULE CARD
EFAROXAN HYDROCHLORIDE
EFAROXAN HYDROCHLORIDE in ChemGrid: 91 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE02300218
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE02300218
- Molecular formula
- C13ClH17N2O
- CAS registry number
- 89197-32-0
- InChIKey
- DWOIUCRHVWIHAH-UHFFFAOYSA-N
- Libraries
- SPECMTS3
- Other recorded names
- Efaroxan hydrochloride
Stored SMILES
Cl.CCC1(Cc2ccccc2O1)C1NCCN=1Matched external records: PubChem 11957548
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
91 measurements across 91 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Adra1b · Adrenergic receptor alpha-1 | ChEMBL | No stored yeast mapping |
| Adra2b · Alpha-2 adrenergic receptor | ChEMBL | No stored yeast mapping |
| ampC · Beta-lactamase | ChEMBL | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL | HDA1 YNL021W (ortholog_one2one) |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| TARDBP · TAR DNA-binding protein 43 | ChEMBL | PIN4 YBL051C (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete EFAROXAN HYDROCHLORIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.