CHEMGRID MOLECULE CARD
CLOMIPRAMINE HYDROCHLORIDE
CLOMIPRAMINE HYDROCHLORIDE in ChemGrid: 616 screened assays, 186 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE02300061
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE02300061
- Molecular formula
- C19Cl2H24N2
- InChIKey
- WIMWMKZEIBHDTH-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, SpectrumTMP, Spectrum_ED
- Other recorded names
- Clomipramine Hydrochloride
Stored SMILES
Cl.CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12Matched external records: PubChem 68539
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
616 measurements across 616 distinct library–species–strain assays; 186 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| FEN24h | SpectrumTMP | 4932 | -35.89 |
| CRA21h | SpectrumTMP | 4932 | -35.40 |
| CYC24h | SpectrumTMP | 4932 | -34.87 |
| CAN24h | SpectrumTMP | 4932 | -34.84 |
| PEU21h | SpectrumTMP | 4932 | -32.52 |
| BUT24h | SpectrumTMP | 4932 | -31.33 |
| PEU24h | SpectrumTMP | 4932 | -30.96 |
| CRA24h | SpectrumTMP | 4932 | -30.61 |
| BBR_HET_tri_24h | SpectrumTMP | 4932 | -26.79 |
| LEN24h | SpectrumTMP | 4932 | -26.36 |
| BUT21h | SpectrumTMP | 4932 | -22.74 |
| pdr1pdr3-24h | SpectrumTMP | 4932 | -20.95 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL | No stored yeast mapping |
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL | No stored yeast mapping |
| RAPGEF3 · Rap guanine nucleotide exchange factor 3 | ChEMBL | LTE1 YAL024C (ortholog_many2many); CDC25 YLR310C (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| THRB · Thyroid hormone receptor beta | ChEMBL | No stored yeast mapping |
| TIM10 · Mitochondrial import inner membrane translocase subunit TIM10 | ChEMBL | MRS5 YBR091C (ortholog_one2many); MRS11 YHR005C-A (ortholog_one2many) |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| GLP1R · Glucagon-like peptide 1 receptor | ChEMBL analogue | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL analogue | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL analogue | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL analogue | No stored yeast mapping |
| NR1H4 · Bile acid receptor | ChEMBL analogue | No stored yeast mapping |
| RAPGEF3 · Rap guanine nucleotide exchange factor 3 | ChEMBL analogue | LTE1 YAL024C (ortholog_many2many); CDC25 YLR310C (ortholog_many2many) |
| RXRA · Retinoic acid receptor RXR-alpha | ChEMBL analogue | No stored yeast mapping |
| Slc6a2 · Norepinephrine transporter | ChEMBL analogue | No stored yeast mapping |
| SLC6A2 · Sodium-dependent noradrenaline transporter | ChEMBL analogue | No stored yeast mapping |
| Slc6a3 · Sodium-dependent dopamine transporter | ChEMBL analogue | No stored yeast mapping |
| Slc6a4 · Sodium-dependent serotonin transporter | ChEMBL analogue | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
| THRB · Thyroid hormone receptor beta | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete CLOMIPRAMINE HYDROCHLORIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.