CHEMGRID MOLECULE CARD
SPERMINE
SPERMINE in ChemGrid: 13 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505764
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505764
- Molecular formula
- C10H26N4
- CAS registry number
- 71-44-3
- InChIKey
- PFNFFQXMRSDOHW-UHFFFAOYSA-N
- Libraries
- Spectrum_ED
- Other recorded names
- Spermine
Stored SMILES
NCCCNCCCCNCCCNMatched external records: PubChem 1103
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
13 measurements across 13 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CA14 · Carbonic anhydrase 14 | ChEMBL | No stored yeast mapping |
| CA4 · Carbonic anhydrase 4 | ChEMBL | No stored yeast mapping |
| CA5A · Carbonic anhydrase 5A, mitochondrial | ChEMBL | No stored yeast mapping |
| CA5B · Carbonic anhydrase 5B, mitochondrial | ChEMBL | No stored yeast mapping |
| CA6 · Carbonic anhydrase 6 | ChEMBL | No stored yeast mapping |
| CA7 · Carbonic anhydrase 7 | ChEMBL | No stored yeast mapping |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL | No stored yeast mapping |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL analogue | No stored yeast mapping |
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| POLK · DNA polymerase kappa | ChEMBL analogue | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete SPERMINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.