CHEMGRID MOLECULE CARD
ROLIPRAM
ROLIPRAM in ChemGrid: 91 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505683
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505683
- Molecular formula
- C16H21NO3
- CAS registry number
- 61413-54-5
- InChIKey
- HJORMJIFDVBMOB-UHFFFAOYSA-N
- Libraries
- SPECMTS3
- Other recorded names
- Rolipram
Stored SMILES
COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1Matched external records: PubChem 5092
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
91 measurements across 91 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| PDE4A · 3',5'-cyclic-AMP phosphodiesterase 4A | ChEMBL | No stored yeast mapping |
| PDE4B · 3',5'-cyclic-AMP phosphodiesterase 4B | ChEMBL | No stored yeast mapping |
| Pde4b · Phosphodiesterase 4 | ChEMBL | No stored yeast mapping |
| PDE4C · 3',5'-cyclic-AMP phosphodiesterase 4C | ChEMBL | No stored yeast mapping |
| PDE4D · 3',5'-cyclic-AMP phosphodiesterase 4D | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete ROLIPRAM research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.