CHEMGRID MOLECULE CARD
NIACINAMIDE
NIACINAMIDE in ChemGrid: 104 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505397
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505397
- Molecular formula
- C6H6N2O
- CAS registry number
- 98-92-0
- InChIKey
- DFPAKSUCGFBDDF-UHFFFAOYSA-N
- Libraries
- SPECMTS3, Spectrum_ED
- Other recorded names
- Nicotinamide
Stored SMILES
NC(=O)c1cccnc1Matched external records: PubChem 936
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
104 measurements across 104 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| Faah · Fatty-acid amide hydrolase 1 | ChEMBL | SCS7 YMR272C (ortholog_one2one) |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| SARM1 · NAD(+) hydrolase SARM1 | ChEMBL | No stored yeast mapping |
| SIR2RP1 · Putative silent information regulator 2 | ChEMBL | No stored yeast mapping |
| SIRT1 · NAD-dependent protein deacetylase sirtuin-1 | ChEMBL | SIR2 YDL042C (ortholog_one2many); HST1 YOL068C (ortholog_one2many) |
| Sirt2 · NAD-dependent protein deacetylase | ChEMBL | HST2 YPL015C (ortholog_one2one) |
| SIRT2 · NAD-dependent protein deacetylase sirtuin-2 | ChEMBL | HST2 YPL015C (ortholog_one2one) |
| SIRT3 · NAD-dependent protein deacetylase sirtuin-3, mitochondrial | ChEMBL | No stored yeast mapping |
| SIRT4 · NAD-dependent protein lipoamidase sirtuin-4, mitochondrial | ChEMBL | No stored yeast mapping |
| SIRT5 · NAD-dependent protein deacylase sirtuin-5, mitochondrial | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete NIACINAMIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.