CHEMGRID MOLECULE CARD
VARDENAFIL HYDROCHLORIDE
VARDENAFIL HYDROCHLORIDE in ChemGrid: 104 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505374
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505374
- Molecular formula
- C23ClH33N6O4S
- CAS registry number
- 224789-15-5
- InChIKey
- XCMULUAPJXCOHI-UHFFFAOYSA-N
- Libraries
- SPECMTS3, Spectrum_ED
- Other recorded names
- Vardenafil Hydrochloride
Stored SMILES
Cl.CCCc1nc(C)c2n1N=C(NC2=O)c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1Matched external records: PubChem 135438569
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
104 measurements across 104 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| PDE1B · Phosphodiesterase 1 | ChEMBL | No stored yeast mapping |
| PDE3A · Phosphodiesterase 3 | ChEMBL | No stored yeast mapping |
| PDE4A · Phosphodiesterase 4 | ChEMBL | No stored yeast mapping |
| PDE5A · cGMP-specific 3',5'-cyclic phosphodiesterase | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete VARDENAFIL HYDROCHLORIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.