CHEMGRID MOLECULE CARD
RANOLAZINE
RANOLAZINE in ChemGrid: 104 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505366
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505366
- Molecular formula
- C24H33N3O4
- CAS registry number
- 95635-55-5
- InChIKey
- XKLMZUWKNUAPSZ-UHFFFAOYSA-N
- Libraries
- SPECMTS3, Spectrum_ED
- Other recorded names
- Ranolazine
Stored SMILES
COc1ccccc1OCC(O)CN1CCN(CC1)CC(=O)Nc1c(C)cccc1CMatched external records: PubChem 56959
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
104 measurements across 104 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADRA1A · Alpha-1A adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRA2C · Alpha-2C adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRB1 · Beta-1 adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRB2 · Beta-2 adrenergic receptor | ChEMBL | No stored yeast mapping |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL | No stored yeast mapping |
| SCN5A · Sodium channel protein type 5 subunit alpha | ChEMBL | No stored yeast mapping |
| SCN5A · Voltage-gated sodium channel Nav1.5 cardiac isoform | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete RANOLAZINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.