CHEMGRID MOLECULE CARD
7-NITROINDAZOLE
7-NITROINDAZOLE in ChemGrid: 104 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505342
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505342
- Molecular formula
- C7H5N3O2
- CAS registry number
- 2942-42-9
- InChIKey
- PQCAUHUKTBHUSA-UHFFFAOYSA-N
- Libraries
- SPECMTS3, Spectrum_ED
- Other recorded names
- 7-Nitroindazole
Stored SMILES
[O-][N+](=O)c1cccc2cnnc21Matched external records: PubChem 1893
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
104 measurements across 104 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| HPGD · 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | ChEMBL | AYR1 YIL124W (ortholog_one2one) |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| Nos1 · Nitric oxide synthase 1 [CHEMBL3048] | ChEMBL | MET10 YFR030W (ortholog_many2many); ECM17 YJR137C (ortholog_many2many) |
| NOS1 · Nitric oxide synthase 1 [CHEMBL3568] | ChEMBL | MET10 YFR030W (ortholog_many2many); ECM17 YJR137C (ortholog_many2many) |
| Nos2 · Nitric oxide synthase, inducible | ChEMBL | No stored yeast mapping |
| Nos3 · Nitric oxide synthase 3 [CHEMBL1075230] | ChEMBL | MET10 YFR030W (ortholog_many2many); ECM17 YJR137C (ortholog_many2many) |
| NOS3 · Nitric oxide synthase 3 [CHEMBL4803] | ChEMBL | MET10 YFR030W (ortholog_many2many); ECM17 YJR137C (ortholog_many2many) |
| POLK · DNA polymerase kappa | ChEMBL | TRF5 YNL299W (ortholog_many2many); PAP2 YOL115W (ortholog_many2many) |
| RECQL · ATP-dependent DNA helicase Q1 | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 7-NITROINDAZOLE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.