CHEMGRID MOLECULE CARD
DIBENZOYLMETHANE
DIBENZOYLMETHANE in ChemGrid: 104 screened assays, 103 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505311
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505311
- Molecular formula
- C15H12O2
- CAS registry number
- 120-46-7
- InChIKey
- NZZIMKJIVMHWJC-UHFFFAOYSA-N
- Libraries
- SPECMTS3, Spectrum_ED
- Other recorded names
- Dibenzoylmethane
Stored SMILES
O=C(CC(=O)c1ccccc1)c1ccccc1Matched external records: PubChem 8433
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
104 measurements across 104 distinct library–species–strain assays; 103 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| pep5 | SPECMTS3 | 4932 | -50.84 |
| ssb2 | SPECMTS3 | 4932 | -50.29 |
| faa2 | SPECMTS3 | 4932 | -48.27 |
| rpn1 | SPECMTS3 | 4932 | -46.77 |
| rbl2 | SPECMTS3 | 4932 | -46.05 |
| bck1 | SPECMTS3 | 4932 | -45.32 |
| skt5 | SPECMTS3 | 4932 | -43.73 |
| arl3 | SPECMTS3 | 4932 | -42.38 |
| MT2481-pdr1pdr3-1st | SPECMTS3 | 4932 | -41.94 |
| swe1 | SPECMTS3 | 4932 | -41.44 |
| sur2 | SPECMTS3 | 4932 | -40.86 |
| tpk1 | SPECMTS3 | 4932 | -40.78 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Liver carboxylesterase 1 | ChEMBL | No stored yeast mapping |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| GNAS · Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ChEMBL | GPA2 YER020W (ortholog_many2many); GPA1 YHR005C (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete DIBENZOYLMETHANE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.