CHEMGRID MOLECULE CARD
TEGASEROD MALEATE
TEGASEROD MALEATE in ChemGrid: 192 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505215
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505215
- Molecular formula
- C20H27N5O5
- CAS registry number
- 189188-57-6
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- Tegaserod Maleate
Stored SMILES
CCCCCNC(=N)NN=Cc1cnc2ccc(OC)cc21.OC(=O)C=CC(O)=OMatched external records: PubChem 135413539
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| DRD2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD4 · D(4) dopamine receptor | ChEMBL | No stored yeast mapping |
| HTR1A · 5-hydroxytryptamine receptor 1A | ChEMBL | No stored yeast mapping |
| HTR1D · 5-hydroxytryptamine receptor 1D | ChEMBL | No stored yeast mapping |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL | No stored yeast mapping |
| HTR2C · 5-hydroxytryptamine receptor 2C | ChEMBL | No stored yeast mapping |
| HTR5A · 5-hydroxytryptamine receptor 5A | ChEMBL | No stored yeast mapping |
| IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic | ChEMBL | IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many) |
| MBD4 · Methyl-CpG-binding domain protein 4 | ChEMBL | No stored yeast mapping |
| SIGMAR1 · Sigma non-opioid intracellular receptor 1 | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| TMEM97 · Sigma intracellular receptor 2 | ChEMBL | YLR050C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete TEGASEROD MALEATE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.