CHEMGRID MOLECULE CARD
TORSEMIDE
TORSEMIDE in ChemGrid: 101 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505211
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505211
- Molecular formula
- C16H20N4O3S
- InChIKey
- NGBFQHCMQULJNZ-UHFFFAOYSA-N
- Libraries
- Spectrum
- Other recorded names
- Torasemide
Stored SMILES
CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc1cccc(C)c1Matched external records: PubChem 41781
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
101 measurements across 101 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ampC · Beta-lactamase | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| CTRC · Chymotrypsin-C | ChEMBL | No stored yeast mapping |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL | No stored yeast mapping |
| CYP3A4 · Cytochrome P450 3A4 | ChEMBL | No stored yeast mapping |
| HIF1A · Hypoxia-inducible factor 1-alpha | ChEMBL | No stored yeast mapping |
| Hsf1 · Heat shock factor protein 1 | ChEMBL | HSF1 YGL073W (ortholog_many2many); HMS2 YJR147W (ortholog_many2many) |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| MDH1 · Malate dehydrogenase, cytoplasmic | ChEMBL | No stored yeast mapping |
| TBXA2R · Thromboxane A2 receptor | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete TORSEMIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.