CHEMGRID MOLECULE CARD
2-,4--DIHYDROXY-4-METHOXYCHALCONE
2-,4--DIHYDROXY-4-METHOXYCHALCONE in ChemGrid: 104 screened assays, 104 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505152
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505152
- Molecular formula
- C16H14O4
- CAS registry number
- 81674-91-1
- InChIKey
- ADRQFDIWPRFKSP-UHFFFAOYSA-N
- Libraries
- SPECMTS3, Spectrum_ED
- Other recorded names
- 2a(2),4a(2)-Dihydroxy-4-methoxychalcone
Stored SMILES
COc1ccc(C=CC(=O)c2ccc(O)cc2O)cc1Matched external records: PubChem 166795
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
104 measurements across 104 distinct library–species–strain assays; 104 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| lat1 | SPECMTS3 | 4932 | -45.40 |
| hsp104 | SPECMTS3 | 4932 | -41.95 |
| bck1 | SPECMTS3 | 4932 | -41.31 |
| gyp1 | SPECMTS3 | 4932 | -36.64 |
| vid30 | SPECMTS3 | 4932 | -36.15 |
| cin8 | SPECMTS3 | 4932 | -36.10 |
| swi4 | SPECMTS3 | 4932 | -36.10 |
| hxk2 | SPECMTS3 | 4932 | -34.30 |
| arl3 | SPECMTS3 | 4932 | -34.29 |
| aat2 | SPECMTS3 | 4932 | -33.50 |
| tpk1 | SPECMTS3 | 4932 | -32.59 |
| chs3 | SPECMTS3 | 4932 | -32.55 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
No source-labelled target annotations are stored for this identifier in this snapshot. This does not mean the molecule has no biological targets.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 2-,4--DIHYDROXY-4-METHOXYCHALCONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.