CHEMGRID MOLECULE CARD
MANGIFERIN
MANGIFERIN in ChemGrid: 104 screened assays, 2 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505134
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505134
- Molecular formula
- C19H18O11
- CAS registry number
- 4773-96-0
- InChIKey
- AEDDIBAIWPIIBD-UHFFFAOYSA-N
- Libraries
- SPECMTS3, Spectrum_ED
- Other recorded names
- 1,3,6,7-Tetrahydroxy-2-(3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)xanthen-9-one
Stored SMILES
OCC1OC(C(O)C(O)C1O)c1c(O)cc2Oc3cc(O)c(O)cc3C(=O)c2c1OMatched external records: PubChem 5358385
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
104 measurements across 104 distinct library–species–strain assays; 2 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| doc1 | SPECMTS3 | 4932 | 4.89 |
| pfk2 | SPECMTS3 | 4932 | 4.04 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Large T antigen | ChEMBL | No stored yeast mapping |
| ALPG · Alkaline phosphatase, germ cell type | ChEMBL | No stored yeast mapping |
| ALPI · Intestinal-type alkaline phosphatase | ChEMBL | PHO8 YDR481C (ortholog_one2many) |
| ALPL · Alkaline phosphatase, tissue-nonspecific isozyme | ChEMBL | PHO8 YDR481C (ortholog_one2many) |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| BAZ2B · Bromodomain adjacent to zinc finger domain protein 2B | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| KDM4A · Lysine-specific demethylase 4A | ChEMBL | YJR119C (ortholog_one2many) |
| L3MBTL1 · Lethal(3)malignant brain tumor-like protein 1 | ChEMBL | No stored yeast mapping |
| NR2E3 · Photoreceptor-specific nuclear receptor | ChEMBL | No stored yeast mapping |
| PPARG · Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete MANGIFERIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.