CHEMGRID MOLECULE CARD
PLUMBAGIN
PLUMBAGIN in ChemGrid: 104 screened assays, 103 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01505129
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01505129
- Molecular formula
- C11H8O3
- CAS registry number
- 481-42-5
- InChIKey
- VCMMXZQDRFWYSE-UHFFFAOYSA-N
- Libraries
- SPECMTS3, Spectrum_ED
- Other recorded names
- Plumbagin
Stored SMILES
Cc1cc(=O)c2c(O)cccc2c1=OMatched external records: PubChem 10205
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
104 measurements across 104 distinct library–species–strain assays; 103 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| BY4743 | Spectrum_ED | 4932 | -71.55 |
| BY4741 | SPECMTS3 | 4932 | -58.10 |
| BY4741-3rd | Spectrum_ED | 4932 | -57.46 |
| nat1 | SPECMTS3 | 4932 | -55.14 |
| paf1 | SPECMTS3 | 4932 | -54.83 |
| hsp104 | SPECMTS3 | 4932 | -54.17 |
| srl3 | SPECMTS3 | 4932 | -53.81 |
| snc1 | SPECMTS3 | 4932 | -53.68 |
| rbl2 | SPECMTS3 | 4932 | -53.08 |
| sdh2 | SPECMTS3 | 4932 | -52.86 |
| hsp82 | SPECMTS3 | 4932 | -52.65 |
| gyp1 | SPECMTS3 | 4932 | -52.03 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| CDC25A · M-phase inducer phosphatase 1 | ChEMBL | YGR203W (ortholog_many2many); MIH1 YMR036C (ortholog_many2many); ARR2 YPR200C (ortholog_many2many) |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| groL · GroEL/GroES | ChEMBL | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| TP53 · Cellular tumor antigen p53 | ChEMBL | No stored yeast mapping |
| TRPA1 · Transient receptor potential cation channel subfamily A member 1 | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete PLUMBAGIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.