CHEMGRID MOLECULE CARD
LOSARTAN
LOSARTAN in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01504268
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01504268
- Molecular formula
- C22ClH23N6O
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Losartan
Stored SMILES
CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)c1ccccc1c1nnnn1Matched external records: PubChem 3961
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Angiotensin II receptor (AT-1) type-1 | ChEMBL | No stored yeast mapping |
| Angiotensin II receptor [CHEMBL2094112] | ChEMBL | No stored yeast mapping |
| Angiotensin II receptor [CHEMBL2094256] | ChEMBL | No stored yeast mapping |
| AGTR1 · Type-1 angiotensin II receptor [CHEMBL1671613] | ChEMBL | No stored yeast mapping |
| AGTR1 · Type-1 angiotensin II receptor [CHEMBL227] | ChEMBL | No stored yeast mapping |
| AGTR1 · Type-1 angiotensin II receptor [CHEMBL3948] | ChEMBL | No stored yeast mapping |
| Agtr1 · Type-1 angiotensin II receptor A | ChEMBL | No stored yeast mapping |
| Agtr1b · Type-1 angiotensin II receptor B | ChEMBL | No stored yeast mapping |
| AGTR2 · Type-2 angiotensin II receptor | ChEMBL | No stored yeast mapping |
| CNR1 · Cannabinoid receptor 1 | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete LOSARTAN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.