CHEMGRID MOLECULE CARD
N,N-HEXAMETHYLENEAMILORIDE
N,N-HEXAMETHYLENEAMILORIDE in ChemGrid: 114 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01504215
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01504215
- Molecular formula
- C12ClH18N7O
- InChIKey
- RQQJJXVETXFINY-UHFFFAOYSA-N
- Libraries
- Spectrum, Spectrum_ED
- Other recorded names
- Hexamethylene amiloride
Stored SMILES
NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1Matched external records: PubChem 1794
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
114 measurements across 114 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| htz1 | Spectrum | 4932 | 4.05 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADORA2B · Adenosine A2 receptor | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL | NCR1 YPL006W (ortholog_one2one) |
| PLAU · Urokinase-type plasminogen activator | ChEMBL | No stored yeast mapping |
| Slc9a1 · Sodium/hydrogen exchanger 1 | ChEMBL | NHX1 YDR456W (ortholog_one2many) |
| Slc9a3 · Sodium/hydrogen exchanger 3 | ChEMBL | NHX1 YDR456W (ortholog_one2many) |
| SLC9A5 · Sodium/hydrogen exchanger 5 | ChEMBL | NHX1 YDR456W (ortholog_one2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| ADORA2B · Adenosine A2 receptor | ChEMBL analogue | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| MPHOSPH8 · M-phase phosphoprotein 8 | ChEMBL analogue | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL analogue | NCR1 YPL006W (ortholog_one2one) |
| PLAU · Urokinase-type plasminogen activator | ChEMBL analogue | No stored yeast mapping |
| Slc9a1 · Sodium/hydrogen exchanger 1 | ChEMBL analogue | NHX1 YDR456W (ortholog_one2many) |
| Slc9a3 · Sodium/hydrogen exchanger 3 | ChEMBL analogue | NHX1 YDR456W (ortholog_one2many) |
| SLC9A5 · Sodium/hydrogen exchanger 5 | ChEMBL analogue | NHX1 YDR456W (ortholog_one2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete N,N-HEXAMETHYLENEAMILORIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.