CHEMGRID MOLECULE CARD
FLUOXETINE
FLUOXETINE in ChemGrid: 616 screened assays, 10 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01504173
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01504173
- Molecular formula
- C17ClF3H19NO
- CAS registry number
- 54910-89-3
- InChIKey
- GIYXAJPCNFJEHY-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, SpectrumTMP, Spectrum_ED
- Other recorded names
- Reconcile
Stored SMILES
Cl.CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1Matched external records: PubChem 62857
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
616 measurements across 616 distinct library–species–strain assays; 10 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| SAM18h | SpectrumTMP | 4932 | 11.18 |
| DHA18h | SpectrumTMP | 4932 | 10.80 |
| NIF18h | SpectrumTMP | 4932 | 8.60 |
| FAS18h | SpectrumTMP | 4932 | 5.88 |
| DAM18h | SpectrumTMP | 4932 | 5.38 |
| rgp1 | SPECMTS3 | 4932 | 5.18 |
| ric1 | Spectrum | 4932 | 5.04 |
| YPT6 | Spectrum | 4932 | 4.72 |
| wSAL21 | SpectrumTMP | 4932 | -4.14 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ATXN2 · Ataxin-2 | ChEMBL | No stored yeast mapping |
| CX3CR1 · CX3C chemokine receptor 1 | ChEMBL | No stored yeast mapping |
| FPR3 · N-formyl peptide receptor 3 | ChEMBL | No stored yeast mapping |
| GPR65 · G-protein coupled receptor 65 | ChEMBL | No stored yeast mapping |
| HTR2C · 5-hydroxytryptamine receptor 2C | ChEMBL | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| RAN · GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | ChEMBL | GSP1 YLR293C (ortholog_one2many); GSP2 YOR185C (ortholog_one2many) |
| Slc6a2 · Transporter | ChEMBL | No stored yeast mapping |
| Slc6a3 · Sodium-dependent dopamine transporter | ChEMBL | No stored yeast mapping |
| Slc6a4 · Sodium-dependent serotonin transporter | ChEMBL | No stored yeast mapping |
| SLC6A4 · Sodium-dependent serotonin transporter [CHEMBL228] | ChEMBL | No stored yeast mapping |
| Slc6a4 · Sodium-dependent serotonin transporter [CHEMBL313] | ChEMBL | No stored yeast mapping |
| UBE2N · Ubiquitin-conjugating enzyme E2 N | ChEMBL | No stored yeast mapping |
| CX3CR1 · CX3C chemokine receptor 1 | ChEMBL analogue | No stored yeast mapping |
| GPR65 · G-protein coupled receptor 65 | ChEMBL analogue | No stored yeast mapping |
| HTR2C · 5-hydroxytryptamine receptor 2C | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| RAN · GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | ChEMBL analogue | GSP1 YLR293C (ortholog_one2many); GSP2 YOR185C (ortholog_one2many) |
| Slc6a2 · Transporter | ChEMBL analogue | No stored yeast mapping |
| Slc6a3 · Sodium-dependent dopamine transporter | ChEMBL analogue | No stored yeast mapping |
| Slc6a4 · Sodium-dependent serotonin transporter | ChEMBL analogue | No stored yeast mapping |
| UBE2N · Ubiquitin-conjugating enzyme E2 N | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete FLUOXETINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.