CHEMGRID MOLECULE CARD
VENLAFAXINE
VENLAFAXINE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01504171
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01504171
- Molecular formula
- C17ClH28NO2
- InChIKey
- QYRYFNHXARDNFZ-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- VENLAFAXINE HYDROCHLORIDE; Venlafaxine; Venlafaxine Hydrochloride
Stored SMILES
Cl.COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1Matched external records: PubChem 5656 PubChem 62923
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Adra1a · Alpha-1A adrenergic receptor | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| Htr1a · 5-hydroxytryptamine receptor 1A | ChEMBL | No stored yeast mapping |
| HTR2A · 5-hydroxytryptamine receptor 2A [CHEMBL224] | ChEMBL | No stored yeast mapping |
| Htr2a · 5-hydroxytryptamine receptor 2A [CHEMBL322] | ChEMBL | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL | No stored yeast mapping |
| pfk · ATP-dependent 6-phosphofructokinase | ChEMBL | No stored yeast mapping |
| rep · Replicase polyprotein 1ab | ChEMBL | No stored yeast mapping |
| Slc6a2 · Norepinephrine transporter | ChEMBL | No stored yeast mapping |
| SLC6A2 · Sodium-dependent noradrenaline transporter | ChEMBL | No stored yeast mapping |
| Slc6a2 · Transporter | ChEMBL | No stored yeast mapping |
| SLC6A3 · Sodium-dependent dopamine transporter | ChEMBL | No stored yeast mapping |
| SLC6A3 · Sodium-dependent dopamine transporter [CHEMBL238] | ChEMBL | No stored yeast mapping |
| Slc6a3 · Sodium-dependent dopamine transporter [CHEMBL338] | ChEMBL | No stored yeast mapping |
| SLC6A4 · Sodium-dependent serotonin transporter | ChEMBL | No stored yeast mapping |
| SLC6A4 · Sodium-dependent serotonin transporter [CHEMBL228] | ChEMBL | No stored yeast mapping |
| Slc6a4 · Sodium-dependent serotonin transporter [CHEMBL313] | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete VENLAFAXINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.