CHEMGRID MOLECULE CARD
NORCANTHARIDIN
NORCANTHARIDIN in ChemGrid: 205 screened assays, 3 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01504153
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01504153
- Molecular formula
- C8H8O4
- InChIKey
- JAABVEXCGCXWRR-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-
Stored SMILES
O=C1OC(=O)C2C3CCC(O3)C21Matched external records: PubChem 93004
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 3 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| cla4 | Spectrum | 4932 | -4.39 |
| BCK1 | Spectrum_ED | 4932 | -4.27 |
| HOG1 | Spectrum_ED | 4932 | -4.21 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Serine-threonine protein phosphatase 2A regulatory subunit | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL | No stored yeast mapping |
| PPM1B · Protein phosphatase 1B | ChEMBL | PTC5 YOR090C (ortholog_one2many) |
| PPP1CA · Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | ChEMBL | PPZ1 YML016C (ortholog_one2many) |
| PPP1CC · Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | ChEMBL | PPZ1 YML016C (ortholog_one2many) |
| PPP5C · Serine/threonine-protein phosphatase | ChEMBL | PPT1 YGR123C (ortholog_one2one) |
| PPP5C · Serine/threonine-protein phosphatase 5 | ChEMBL | PPT1 YGR123C (ortholog_one2one) |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| TFPI2 · Tissue factor pathway inhibitor 2 | ChEMBL | No stored yeast mapping |
| Serine-threonine protein phosphatase 2A regulatory subunit | ChEMBL analogue | No stored yeast mapping |
| APP · Amyloid-beta precursor protein | ChEMBL analogue | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL analogue | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MAPK1 · Mitogen-activated protein kinase 1 | ChEMBL analogue | SLT2 YHR030C (ortholog_many2many); YKL161C (ortholog_many2many) |
| NS1 · Nonstructural protein 1 | ChEMBL analogue | No stored yeast mapping |
| PPM1B · Protein phosphatase 1B | ChEMBL analogue | PTC5 YOR090C (ortholog_one2many) |
| PPP1CA · Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | ChEMBL analogue | PPZ1 YML016C (ortholog_one2many) |
| PPP1CC · Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | ChEMBL analogue | PPZ1 YML016C (ortholog_one2many) |
| PPP5C · Serine/threonine-protein phosphatase | ChEMBL analogue | PPT1 YGR123C (ortholog_one2one) |
| PPP5C · Serine/threonine-protein phosphatase 5 | ChEMBL analogue | PPT1 YGR123C (ortholog_one2one) |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| SNCA · Alpha-synuclein | ChEMBL analogue | No stored yeast mapping |
| TFPI2 · Tissue factor pathway inhibitor 2 | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete NORCANTHARIDIN research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.