CHEMGRID MOLECULE CARD
3,7-DIHYDROXYFLAVONE
3,7-DIHYDROXYFLAVONE in ChemGrid: 205 screened assays, 165 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01504130
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01504130
- Molecular formula
- C15H10O4
- CAS registry number
- 492-00-2
- InChIKey
- UWQJWDYDYIJWKY-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- 3,7-Dihydroxyflavone
Stored SMILES
Oc1ccc2C(=O)C(O)=C(Oc2c1)c1ccccc1Matched external records: PubChem 5393152
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 165 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| fet3 | SPECMTS3 | 4932 | -37.62 |
| pep5 | SPECMTS3 | 4932 | -36.75 |
| ssb2 | SPECMTS3 | 4932 | -36.51 |
| bck1 | SPECMTS3 | 4932 | -33.66 |
| rpn1 | SPECMTS3 | 4932 | -33.56 |
| KRE1 | Spectrum | 4932 | -31.89 |
| BY4741 | Spectrum | 4932 | -30.63 |
| faa2 | SPECMTS3 | 4932 | -30.01 |
| CNB1 | Spectrum | 4932 | -29.68 |
| SLT2 | Spectrum | 4932 | -27.95 |
| PPZ1 | Spectrum | 4932 | -27.53 |
| tpk1 | SPECMTS3 | 4932 | -27.37 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX12 · Polyunsaturated fatty acid lipoxygenase ALOX12 | ChEMBL | No stored yeast mapping |
| ALOX15 · Polyunsaturated fatty acid lipoxygenase ALOX15 | ChEMBL | No stored yeast mapping |
| ALOX15B · Polyunsaturated fatty acid lipoxygenase ALOX15B | ChEMBL | No stored yeast mapping |
| CASP1 · Caspase-1 | ChEMBL | No stored yeast mapping |
| CASP7 · Caspase-7 | ChEMBL | No stored yeast mapping |
| fabI · Enoyl-acyl-carrier protein reductase | ChEMBL | No stored yeast mapping |
| FTL · Ferritin light chain | ChEMBL | No stored yeast mapping |
| HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2 | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL | No stored yeast mapping |
| ABCG2 · Broad substrate specificity ATP-binding cassette transporter ABCG2 | ChEMBL analogue | SNQ2 YDR011W (ortholog_many2many); PDR15 YDR406W (ortholog_many2many); PDR11 YIL013C (ortholog_many2many); YNR070W (ortholog_many2many); AUS1 YOR011W (ortholog_many2many); PDR5 YOR153W (ortholog_many2many); PDR10 YOR328W (ortholog_many2many); PDR12 YPL058C (ortholog_many2many) |
| ACHE · Acetylcholinesterase | ChEMBL analogue | No stored yeast mapping |
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL analogue | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| ATXN2 · Ataxin-2 | ChEMBL analogue | No stored yeast mapping |
| CA1 · Carbonic anhydrase 1 | ChEMBL analogue | No stored yeast mapping |
| CDK1 · Cyclin-dependent kinase 1/cyclin B | ChEMBL analogue | CDC28 YBR160W (ortholog_one2many) |
| CDK5 · Cyclin-dependent kinase 5/CDK5 activator 1 | ChEMBL analogue | No stored yeast mapping |
| CDK6 · Cyclin-dependent kinase 6 | ChEMBL analogue | No stored yeast mapping |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL analogue | No stored yeast mapping |
| CSNK2A1 · Casein kinase II subunit alpha | ChEMBL analogue | CKA1 YIL035C (ortholog_many2many); CKA2 YOR061W (ortholog_many2many) |
| Csnk2b · Casein kinase 2 | ChEMBL analogue | No stored yeast mapping |
| CSNK2B · Casein kinase II | ChEMBL analogue | No stored yeast mapping |
| CYP19A1 · Aromatase | ChEMBL analogue | No stored yeast mapping |
| CYP1B1 · Cytochrome P450 1B1 | ChEMBL analogue | No stored yeast mapping |
| DAPK1 · Death-associated protein kinase 1 | ChEMBL analogue | YML002W (ortholog_many2many); YMR291W (ortholog_many2many) |
| F2 · Prothrombin | ChEMBL analogue | No stored yeast mapping |
| fabG · 3-oxoacyl-acyl-carrier protein reductase | ChEMBL analogue | No stored yeast mapping |
| fabI · Enoyl-acyl-carrier protein reductase | ChEMBL analogue | No stored yeast mapping |
First 30 of 54 target records; open the interactive profile for further evidence.
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 3,7-DIHYDROXYFLAVONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.