CHEMGRID MOLECULE CARD
2-THIOURACIL
2-THIOURACIL in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01503973
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01503973
- Molecular formula
- C4H4N2OS
- CAS registry number
- 141-90-2
- InChIKey
- ZEMGGZBWXRYJHK-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Thiouracil
Stored SMILES
Oc1ccnc(S)n1Matched external records: PubChem 1269845
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX5 · Polyunsaturated fatty acid 5-lipoxygenase | ChEMBL | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL | SMI1 YGR229C (ortholog_one2many) |
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL | No stored yeast mapping |
| lef · Lethal factor | ChEMBL | No stored yeast mapping |
| MMP1 · Interstitial collagenase | ChEMBL | No stored yeast mapping |
| MMP2 · 72 kDa type IV collagenase | ChEMBL | No stored yeast mapping |
| MMP3 · Stromelysin-1 | ChEMBL | No stored yeast mapping |
| MMP8 · Neutrophil collagenase | ChEMBL | No stored yeast mapping |
| MMP9 · Matrix metalloproteinase-9 | ChEMBL | No stored yeast mapping |
| PPO2 · Tyrosinase | ChEMBL | No stored yeast mapping |
| TP53 · Cellular tumor antigen p53 | ChEMBL | No stored yeast mapping |
| ALOX5 · Polyunsaturated fatty acid 5-lipoxygenase | ChEMBL analogue | No stored yeast mapping |
| fba · Fructose-bisphosphate aldolase | ChEMBL analogue | SMI1 YGR229C (ortholog_one2many) |
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL analogue | No stored yeast mapping |
| lef · Lethal factor | ChEMBL analogue | No stored yeast mapping |
| MMP1 · Interstitial collagenase | ChEMBL analogue | No stored yeast mapping |
| MMP2 · 72 kDa type IV collagenase | ChEMBL analogue | No stored yeast mapping |
| MMP3 · Stromelysin-1 | ChEMBL analogue | No stored yeast mapping |
| MMP8 · Neutrophil collagenase | ChEMBL analogue | No stored yeast mapping |
| MMP9 · Matrix metalloproteinase-9 | ChEMBL analogue | No stored yeast mapping |
| PPO2 · Tyrosinase | ChEMBL analogue | No stored yeast mapping |
| TP53 · Cellular tumor antigen p53 | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 2-THIOURACIL research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.