CHEMGRID MOLECULE CARD
LEFLUNOMIDE
LEFLUNOMIDE in ChemGrid: 192 screened assays, 9 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01503927
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01503927
- Molecular formula
- C12F3H9N2O2
- CAS registry number
- 75706-12-6
- InChIKey
- VHOGYURTWQBHIL-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- LEFUNAMIDE; Leflunomide
Stored SMILES
Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)FMatched external records: PubChem 3899
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 9 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| bem2 | SPECMTS3 | 4932 | -7.86 |
| doc1 | SPECMTS3 | 4932 | -7.54 |
| sac3 | SPECMTS3 | 4932 | -7.21 |
| lat1 | SPECMTS3 | 4932 | -6.95 |
| pfk2 | SPECMTS3 | 4932 | -6.62 |
| swc5 | SPECMTS3 | 4932 | -5.35 |
| sur2 | SPECMTS3 | 4932 | -4.54 |
| hhf1 | SPECMTS3 | 4932 | -4.25 |
| trk1 | SPECMTS3 | 4932 | -4.04 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL | No stored yeast mapping |
| ATAD5 · ATPase family AAA domain-containing protein 5 | ChEMBL | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL | No stored yeast mapping |
| DHODH · Dihydroorotate dehydrogenase (quinone), mitochondrial | ChEMBL | No stored yeast mapping |
| DHODH · Dihydroorotate dehydrogenase (quinone), mitochondrial [CHEMBL1966] | ChEMBL | No stored yeast mapping |
| Dhodh · Dihydroorotate dehydrogenase (quinone), mitochondrial [CHEMBL2383] | ChEMBL | No stored yeast mapping |
| Dhodh · Dihydroorotate dehydrogenase (quinone), mitochondrial [CHEMBL2991] | ChEMBL | No stored yeast mapping |
| HRH2 · Histamine H2 receptor | ChEMBL | No stored yeast mapping |
| HTT · Huntingtin | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL | NCR1 YPL006W (ortholog_one2one) |
| NPSR1 · Neuropeptide S receptor | ChEMBL | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| CYP1A2 · Cytochrome P450 1A2 | ChEMBL analogue | No stored yeast mapping |
| DHODH · Dihydroorotate dehydrogenase (quinone), mitochondrial | ChEMBL analogue | No stored yeast mapping |
| HTT · Huntingtin | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| NPC1 · NPC intracellular cholesterol transporter 1 | ChEMBL analogue | NCR1 YPL006W (ortholog_one2one) |
| NPSR1 · Neuropeptide S receptor | ChEMBL analogue | No stored yeast mapping |
| RAB9A · Ras-related protein Rab-9A | ChEMBL analogue | YPT10 YBR264C (ortholog_many2many); YPT31 YER031C (ortholog_many2many); YPT1 YFL038C (ortholog_many2many); YPT32 YGL210W (ortholog_many2many); YPT52 YKR014C (ortholog_many2many); YPT6 YLR262C (ortholog_many2many); TEM1 YML064C (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete LEFLUNOMIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.