CHEMGRID MOLECULE CARD
ISOSORBIDE MONONITRATE
ISOSORBIDE MONONITRATE in ChemGrid: 13 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01503807
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01503807
- Molecular formula
- C6H9NO6
- CAS registry number
- 16051-77-7
- InChIKey
- YWXYYJSYQOXTPL-UHFFFAOYSA-N
- Libraries
- Spectrum_ED
- Other recorded names
- Isosorbide Mononitrate
Stored SMILES
[O-][N+](=O)OC1COC2C(O)COC12Matched external records: PubChem 27661
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
13 measurements across 13 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADRB1 · Beta-1 adrenergic receptor | ChEMBL | No stored yeast mapping |
| ADRB2 · Beta-2 adrenergic receptor | ChEMBL | No stored yeast mapping |
| Cacna1c · Voltage-dependent L-type calcium channel subunit alpha-1C | ChEMBL | CCH1 YGR217W (ortholog_one2many) |
| CHRM1 · Muscarinic acetylcholine receptor M1 | ChEMBL | No stored yeast mapping |
| DRD1 · D(1A) dopamine receptor | ChEMBL | No stored yeast mapping |
| DRD4 · D(4) dopamine receptor | ChEMBL | No stored yeast mapping |
| Gabra1 · Gamma-aminobutyric acid receptor subunit alpha-1 | ChEMBL | No stored yeast mapping |
| Grin1 · Glutamate receptor ionotropic, NMDA 1 | ChEMBL | No stored yeast mapping |
| HRH2 · Histamine H2 receptor | ChEMBL | No stored yeast mapping |
| OPRK1 · Kappa-type opioid receptor | ChEMBL | No stored yeast mapping |
| SLC6A3 · Sodium-dependent dopamine transporter | ChEMBL | No stored yeast mapping |
| TACR1 · Substance-P receptor | ChEMBL | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete ISOSORBIDE MONONITRATE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.