CHEMGRID MOLECULE CARD
PENTOXIFYLLINE
PENTOXIFYLLINE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01503611
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01503611
- Molecular formula
- C13H18N4O3
- CAS registry number
- 6493-05-6
- InChIKey
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Pentoxifylline
Stored SMILES
Cn1cnc2N(C)C(=O)N(CCCCC(C)=O)C(=O)c12Matched external records: PubChem 4740
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Luciferin 4-monooxygenase | ChEMBL | No stored yeast mapping |
| ADORA2B · Adenosine receptor A2b | ChEMBL | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL | SET2 YJL168C (ortholog_many2many) |
| Impa1 · Inositol monophosphatase 1 | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL | No stored yeast mapping |
| RGS4 · Regulator of G-protein signaling 4 | ChEMBL | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| Luciferin 4-monooxygenase | ChEMBL analogue | No stored yeast mapping |
| ADORA2B · Adenosine receptor A2b | ChEMBL analogue | No stored yeast mapping |
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL analogue | No stored yeast mapping |
| Chrm1 · Muscarinic acetylcholine receptor M1 | ChEMBL analogue | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| Impa1 · Inositol monophosphatase 1 | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| POLI · DNA polymerase iota | ChEMBL analogue | No stored yeast mapping |
| RGS4 · Regulator of G-protein signaling 4 | ChEMBL analogue | No stored yeast mapping |
| SMN1 · Survival motor neuron protein | ChEMBL analogue | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL analogue | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete PENTOXIFYLLINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.