CHEMGRID MOLECULE CARD
NITRENDIPINE
NITRENDIPINE in ChemGrid: 192 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01503609
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01503609
- Molecular formula
- C18H20N2O6
- CAS registry number
- 84845-75-0
- InChIKey
- PVHUJELLJLJGLN-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- Nitrendipine
Stored SMILES
[O-][N+](=O)c1cccc(c1)C1C(=C(C)NC(C)=C1C(=O)OCC)C(=O)OCMatched external records: PubChem 4507
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Cacna1c · Voltage-dependent L-type calcium channel subunit alpha-1C | ChEMBL | CCH1 YGR217W (ortholog_one2many) |
| Cacna1c · Voltage-gated L-type calcium channel | ChEMBL | CCH1 YGR217W (ortholog_one2many) |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL | No stored yeast mapping |
| Cacna1c · Voltage-dependent L-type calcium channel subunit alpha-1C | ChEMBL analogue | CCH1 YGR217W (ortholog_one2many) |
| Cacna1c · Voltage-gated L-type calcium channel | ChEMBL analogue | CCH1 YGR217W (ortholog_one2many) |
| CACNA2D1 · L-type calcium channel alpha-1c/beta-2/alpha2delta-1 | ChEMBL analogue | No stored yeast mapping |
| CNR1 · Cannabinoid receptor 1 | ChEMBL analogue | No stored yeast mapping |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL analogue | No stored yeast mapping |
| Impa1 · Inositol monophosphatase 1 | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| NPSR1 · Neuropeptide S receptor | ChEMBL analogue | No stored yeast mapping |
| NR1I2 · Nuclear receptor subfamily 1 group I member 2 | ChEMBL analogue | No stored yeast mapping |
| PDE1C · Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | ChEMBL analogue | No stored yeast mapping |
| Trpa1 · Transient receptor potential cation channel subfamily A member 1 | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete NITRENDIPINE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.