CHEMGRID MOLECULE CARD
EXALAMIDE
EXALAMIDE in ChemGrid: 205 screened assays, 147 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01503403
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01503403
- Molecular formula
- C13H19NO2
- CAS registry number
- 53370-90-4
- InChIKey
- CKSJXOVLXUMMFF-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Exalamide
Stored SMILES
CCCCCCOc1ccccc1C(N)=OMatched external records: PubChem 3316
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 147 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| SLT2 | Spectrum | 4932 | -46.32 |
| pex11 | Spectrum | 4932 | -44.23 |
| tif3 | Spectrum | 4932 | -40.31 |
| mck1 | Spectrum | 4932 | -38.86 |
| MT2481-pdr1pdr3-2nd | Spectrum | 4932 | -38.74 |
| BEM2 | Spectrum | 4932 | -37.62 |
| CNB1 | Spectrum | 4932 | -35.57 |
| CIN2 | Spectrum | 4932 | -34.82 |
| elg1 | Spectrum | 4932 | -32.28 |
| mad1 | Spectrum | 4932 | -32.08 |
| CHS5 | Spectrum | 4932 | -31.27 |
| cnb1-2nd | Spectrum | 4932 | -30.86 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL | No stored yeast mapping |
| Ar · Androgen receptor | ChEMBL | No stored yeast mapping |
| CHRM2 · Muscarinic acetylcholine receptor M2 | ChEMBL | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL | HDA1 YNL021W (ortholog_one2one) |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL | No stored yeast mapping |
| NR1I2 · Nuclear receptor subfamily 1 group I member 2 | ChEMBL | No stored yeast mapping |
| OPRK1 · Kappa-type opioid receptor | ChEMBL | No stored yeast mapping |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL | No stored yeast mapping |
| SLC6A3 · Sodium-dependent dopamine transporter | ChEMBL | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| ADRA2A · Alpha-2A adrenergic receptor | ChEMBL analogue | No stored yeast mapping |
| Ar · Androgen receptor | ChEMBL analogue | No stored yeast mapping |
| CHRM2 · Muscarinic acetylcholine receptor M2 | ChEMBL analogue | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL analogue | HDA1 YNL021W (ortholog_one2one) |
| HTR2B · 5-hydroxytryptamine receptor 2B | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL analogue | No stored yeast mapping |
| NR1I2 · Nuclear receptor subfamily 1 group I member 2 | ChEMBL analogue | No stored yeast mapping |
| OPRK1 · Kappa-type opioid receptor | ChEMBL analogue | No stored yeast mapping |
| Pmp22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| SLC6A3 · Sodium-dependent dopamine transporter | ChEMBL analogue | No stored yeast mapping |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL analogue | TDP1 YBR223C (ortholog_one2one) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete EXALAMIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.