CHEMGRID MOLECULE CARD
CYCLOTHIAZIDE
CYCLOTHIAZIDE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01503263
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01503263
- Molecular formula
- C14ClH16N3O4S2
- CAS registry number
- 2259-96-3
- InChIKey
- BOCUKUHCLICSIY-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Cyclothiazide
Stored SMILES
NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C2CC3CC2C=C3)cc1ClMatched external records: PubChem 2910
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ARSA · Arylsulfatase A | ChEMBL | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| GMNN · Geminin | ChEMBL | No stored yeast mapping |
| GRIA1 · Glutamate receptor 1 | ChEMBL | No stored yeast mapping |
| Gria2 · Glutamate receptor 2 | ChEMBL | No stored yeast mapping |
| GRIA2 · Glutamate receptor AMPA 1/2 | ChEMBL | No stored yeast mapping |
| Gria2 · Glutamate receptor ionotropic, AMPA | ChEMBL | No stored yeast mapping |
| GRIA4 · Glutamate receptor 4 | ChEMBL | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta | ChEMBL | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL analogue | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| GRIA1 · Glutamate receptor 1 | ChEMBL analogue | No stored yeast mapping |
| Gria2 · Glutamate receptor 2 | ChEMBL analogue | No stored yeast mapping |
| GRIA2 · Glutamate receptor AMPA 1/2 | ChEMBL analogue | No stored yeast mapping |
| Gria2 · Glutamate receptor ionotropic, AMPA | ChEMBL analogue | No stored yeast mapping |
| GRIA4 · Glutamate receptor 4 | ChEMBL analogue | No stored yeast mapping |
| LMNA · Prelamin-A/C | ChEMBL analogue | No stored yeast mapping |
| THRB · Thyroid hormone receptor beta | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete CYCLOTHIAZIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.