CHEMGRID MOLECULE CARD

6alpha-METHYLPREDNISOLONE ACETATE

6alpha-METHYLPREDNISOLONE ACETATE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01503254

Explore activity & SONAR

Chemical structure of 6alpha-METHYLPREDNISOLONE ACETATE — Stored molecular structure

205Screened assays

0Significant assay responses

7Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01503254
Molecular formula: C24H32O6
InChIKey: PLBHSZGDDKCEHR-UHFFFAOYSA-N
Libraries: Spectrum, SPECMTS3, Spectrum_ED
Other recorded names: [2-(11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] acetate

Stored SMILES

CC1CC2C3CCC(O)(C(=O)COC(C)=O)C3(C)CC(O)C2C2(C)C=CC(=O)C=C12

Matched external records: PubChem 584547

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
APEX1 · DNA repair nuclease/redox regulator APEX1	ChEMBL analogue	No stored yeast mapping
GLP1R · Glucagon-like peptide 1 receptor	ChEMBL analogue	No stored yeast mapping
GMNN · Geminin	ChEMBL analogue	No stored yeast mapping
IDH1 · Isocitrate dehydrogenase [NADP] cytoplasmic	ChEMBL analogue	IDP1 YDL066W (ortholog_many2many); IDP2 YLR174W (ortholog_many2many); IDP3 YNL009W (ortholog_many2many)
NFE2L2 · Nuclear factor erythroid 2-related factor 2	ChEMBL analogue	No stored yeast mapping
POLI · DNA polymerase iota	ChEMBL analogue	No stored yeast mapping
TDP1 · Tyrosyl-DNA phosphodiesterase 1	ChEMBL analogue	TDP1 YBR223C (ortholog_one2one)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete 6alpha-METHYLPREDNISOLONE ACETATE research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.