CHEMGRID MOLECULE CARD
DOBUTAMINE HYDROCHLORIDE
DOBUTAMINE HYDROCHLORIDE in ChemGrid: 205 screened assays, 45 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01503212
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01503212
- Molecular formula
- C18ClH24NO3
- InChIKey
- KIJPEPDIWFEFJU-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3, Spectrum_ED
- Other recorded names
- Pharmakon1600-01503212
Stored SMILES
Cl.CC(CNCCc1ccc(O)c(O)c1)Cc1cccc(O)c1Matched external records: PubChem 5702225
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
205 measurements across 205 distinct library–species–strain assays; 45 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| DEP1 | Spectrum | 4932 | -17.91 |
| RNR3 | Spectrum | 4932 | -15.30 |
| CIN2 | Spectrum | 4932 | -14.00 |
| Sap30 | Spectrum | 4932 | -13.70 |
| top1-2nd | Spectrum | 4932 | -13.48 |
| NBP2 | Spectrum | 4932 | -12.62 |
| KRE1 | Spectrum | 4932 | -11.81 |
| doa4 | SPECMTS3 | 4932 | -11.56 |
| CNB1 | Spectrum | 4932 | -11.38 |
| CIN8 | Spectrum | 4932 | -9.91 |
| Arp1 | Spectrum | 4932 | -9.13 |
| PPZ1 | Spectrum | 4932 | -9.06 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| APEX1 · DNA repair nuclease/redox regulator APEX1 | ChEMBL | No stored yeast mapping |
| DRD2 · D(2) dopamine receptor | ChEMBL | No stored yeast mapping |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| TDP1 · Tyrosyl-DNA phosphodiesterase 1 | ChEMBL | TDP1 YBR223C (ortholog_one2one) |
| VDR · Vitamin D3 receptor | ChEMBL | No stored yeast mapping |
| EHMT2 · Histone-lysine N-methyltransferase EHMT2 | ChEMBL analogue | SET2 YJL168C (ortholog_many2many) |
| ffp · 4'-phosphopantetheinyl transferase ffp | ChEMBL analogue | No stored yeast mapping |
| GLS · Glutaminase kidney isoform, mitochondrial | ChEMBL analogue | No stored yeast mapping |
| GMNN · Geminin | ChEMBL analogue | No stored yeast mapping |
| Htr2a · 5-hydroxytryptamine receptor 2A | ChEMBL analogue | No stored yeast mapping |
| KCNH2 · Voltage-gated inwardly rectifying potassium channel KCNH2 | ChEMBL analogue | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| OPRM1 · Mu-type opioid receptor | ChEMBL analogue | No stored yeast mapping |
| RAN · GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 | ChEMBL analogue | GSP1 YLR293C (ortholog_one2many); GSP2 YOR185C (ortholog_one2many) |
| SLC5A7 · High affinity choline transporter 1 | ChEMBL analogue | DUR3 YHL016C (ortholog_one2many) |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete DOBUTAMINE HYDROCHLORIDE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.