CHEMGRID MOLECULE CARD
TIOXOLONE
TIOXOLONE in ChemGrid: 192 screened assays, 7 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01503094
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01503094
- Molecular formula
- C7H4O3S
- CAS registry number
- 4991-65-5
- InChIKey
- SLYPOVJCSQHITR-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- THIOXOLONE; 6-Hydroxy-1,3-benzoxathiol-2-one
Stored SMILES
Oc1ccc2SC(=O)Oc2c1Matched external records: PubChem 72139
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 7 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| rad52 | Spectrum | 4932 | -5.96 |
| BY4741-3rd | Spectrum | 4932 | -5.02 |
| arx1 | Spectrum | 4932 | -4.96 |
| bik1 | Spectrum | 4932 | -4.42 |
| mcm21 | Spectrum | 4932 | -4.37 |
| vps1 | Spectrum | 4932 | -4.20 |
| sto1 | SPECMTS3 | 4932 | 4.14 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| Large T antigen | ChEMBL | No stored yeast mapping |
| ALPG · Alkaline phosphatase, germ cell type | ChEMBL | No stored yeast mapping |
| ALPI · Intestinal-type alkaline phosphatase [CHEMBL5573] | ChEMBL | PHO8 YDR481C (ortholog_one2many) |
| ALPL · Alkaline phosphatase, tissue-nonspecific isozyme | ChEMBL | PHO8 YDR481C (ortholog_one2many) |
| CA2 · Carbonic anhydrase 2 | ChEMBL | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL | No stored yeast mapping |
| GLS · Glutaminase kidney isoform, mitochondrial | ChEMBL | No stored yeast mapping |
| Iap · Intestinal-type alkaline phosphatase | ChEMBL | PHO8 YDR481C (ortholog_one2many); OST6 YML019W (ortholog_many2many); OST3 YOR085W (ortholog_many2many) |
| Iap · Intestinal-type alkaline phosphatase [CHEMBL3151] | ChEMBL | PHO8 YDR481C (ortholog_one2many); OST6 YML019W (ortholog_many2many); OST3 YOR085W (ortholog_many2many) |
| MAOA · Amine oxidase [flavin-containing] A | ChEMBL | No stored yeast mapping |
| MAOB · Amine oxidase [flavin-containing] B | ChEMBL | No stored yeast mapping |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| VDR · Vitamin D3 receptor | ChEMBL | No stored yeast mapping |
| Large T antigen | ChEMBL analogue | No stored yeast mapping |
| ALPL · Alkaline phosphatase, tissue-nonspecific isozyme | ChEMBL analogue | PHO8 YDR481C (ortholog_one2many) |
| CA2 · Carbonic anhydrase 2 | ChEMBL analogue | No stored yeast mapping |
| CBX1 · Chromobox protein homolog 1 | ChEMBL analogue | No stored yeast mapping |
| GLS · Glutaminase kidney isoform, mitochondrial | ChEMBL analogue | No stored yeast mapping |
| Iap · Intestinal-type alkaline phosphatase | ChEMBL analogue | PHO8 YDR481C (ortholog_one2many); OST6 YML019W (ortholog_many2many); OST3 YOR085W (ortholog_many2many) |
| NFE2L2 · Nuclear factor erythroid 2-related factor 2 | ChEMBL analogue | No stored yeast mapping |
| Txnrd1 · Thioredoxin reductase 1, cytoplasmic | ChEMBL analogue | TRR1 YDR353W (ortholog_many2many); TRR2 YHR106W (ortholog_many2many) |
| VDR · Vitamin D3 receptor | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete TIOXOLONE research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.