ChemGrid

CHEMGRID MOLECULE CARD

HARMOL HYDROCHLORIDE

HARMOL HYDROCHLORIDE in ChemGrid: 205 screened assays, 0 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01502237

Explore activity & SONAR
Chemical structure of HARMOL HYDROCHLORIDE
Stored molecular structure
205Screened assays
0Significant assay responses
1Source-labelled target records

Identity and chemistry

ChemGrid identifier
SPE01502237
Molecular formula
C12ClH11N2O
CAS registry number
40580-83-4
Libraries
Spectrum, SPECMTS3, Spectrum_ED
Other recorded names
1-Methyl-2,9-dihydro-7H-pyrido(3,4-b)indol-7-one--hydrogen chloride (1/1)
Stored SMILESCl.Cc1nccc2c1nc1cc(O)ccc12

Matched external records: PubChem 94507

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

205 measurements across 205 distinct library–species–strain assays; 0 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

TargetSourceYeast ORF / orthologue
AKR1B1 · Aldo-keto reductase family 1 member B1ChEMBLAAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete HARMOL HYDROCHLORIDE research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.