CHEMGRID MOLECULE CARD
5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB]
5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB] in ChemGrid: 101 screened assays, 17 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01502153
Explore activity & SONAR![Chemical structure of 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB]](/structure-thumbnails/Spectrum/SP/SPE01502153.svg?v=2026-09-22T13%3A54%3A31%2B00%3A00)
Identity and chemistry
- ChemGrid identifier
- SPE01502153
- Molecular formula
- C16H16N2O4
- InChIKey
- WBSMIPAMAXNXFS-UHFFFAOYSA-N
- Libraries
- Spectrum
- Other recorded names
- Nppb
Stored SMILES
[O-][N+](=O)c1ccc(NCCCc2ccccc2)c(c1)C(O)=OMatched external records: PubChem 4549
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
101 measurements across 101 distinct library–species–strain assays; 17 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| cla4 | Spectrum | 4932 | -10.88 |
| mrt4 | Spectrum | 4932 | -9.71 |
| mdh1 | Spectrum | 4932 | -8.76 |
| YKL085W | Spectrum | 4932 | -8.76 |
| nup100 | Spectrum | 4932 | -8.68 |
| kgd1 | Spectrum | 4932 | -8.13 |
| bmi1 | Spectrum | 4932 | -6.23 |
| kar3 | Spectrum | 4932 | -5.98 |
| rad50 | Spectrum | 4932 | -5.91 |
| tfp1 | Spectrum | 4932 | -5.52 |
| dbp3 | Spectrum | 4932 | -5.49 |
| BEM2 | Spectrum | 4932 | -4.59 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ARSA · Arylsulfatase A | ChEMBL | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL | SGS1 YMR190C (ortholog_one2one) |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL | HDA1 YNL021W (ortholog_one2one) |
| HSPA5 · Endoplasmic reticulum chaperone BiP | ChEMBL | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL | No stored yeast mapping |
| PMP22 · Peripheral myelin protein 22 | ChEMBL | No stored yeast mapping |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL | No stored yeast mapping |
| THPO · Thrombopoietin | ChEMBL | No stored yeast mapping |
| TRPA1 · Transient receptor potential cation channel subfamily A member 1 | ChEMBL | No stored yeast mapping |
| TSHR · Thyrotropin receptor | ChEMBL | No stored yeast mapping |
| ARSA · Arylsulfatase A | ChEMBL analogue | No stored yeast mapping |
| BLM · RecQ-like DNA helicase BLM | ChEMBL analogue | SGS1 YMR190C (ortholog_one2one) |
| CYP2C9 · Cytochrome P450 2C9 | ChEMBL analogue | No stored yeast mapping |
| HDAC6 · Protein deacetylase HDAC6 | ChEMBL analogue | HDA1 YNL021W (ortholog_one2one) |
| HSPA5 · Endoplasmic reticulum chaperone BiP | ChEMBL analogue | No stored yeast mapping |
| MAPT · Microtubule-associated protein tau | ChEMBL analogue | No stored yeast mapping |
| PMP22 · Peripheral myelin protein 22 | ChEMBL analogue | No stored yeast mapping |
| PTH1R · Parathyroid hormone/parathyroid hormone-related peptide receptor | ChEMBL analogue | No stored yeast mapping |
| THPO · Thrombopoietin | ChEMBL analogue | No stored yeast mapping |
| TRPA1 · Transient receptor potential cation channel subfamily A member 1 | ChEMBL analogue | No stored yeast mapping |
| TSHR · Thyrotropin receptor | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB] research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.