CHEMGRID MOLECULE CARD
GOSSYPOL-ACETIC ACID COMPLEX
GOSSYPOL-ACETIC ACID COMPLEX in ChemGrid: 192 screened assays, 110 with significant responses. Explore chemical identifiers, strain activity and target evidence.
SPE01502099
Explore activity & SONAR
Identity and chemistry
- ChemGrid identifier
- SPE01502099
- Molecular formula
- C32H34O10
- InChIKey
- NIOHNDKHQHVLKA-UHFFFAOYSA-N
- Libraries
- Spectrum, SPECMTS3
- Other recorded names
- Gossypol Acetic Acid
Stored SMILES
CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O.CC(O)=OMatched external records: PubChem 227456
Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.
Measured chemical–genetic activity
192 measurements across 192 distinct library–species–strain assays; 110 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).
Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.
| Strain | Library | Species identifier | Z-score |
|---|---|---|---|
| pep5 | SPECMTS3 | 4932 | -39.06 |
| fet3 | SPECMTS3 | 4932 | -36.75 |
| MT2481-pdr1pdr3-1st | SPECMTS3 | 4932 | -27.95 |
| ccr4 | SPECMTS3 | 4932 | -26.95 |
| arl3 | SPECMTS3 | 4932 | -26.60 |
| MT2481-pdr1pdr3-2nd | SPECMTS3 | 4932 | -25.83 |
| ssb2 | SPECMTS3 | 4932 | -25.17 |
| ypt6 | SPECMTS3 | 4932 | -22.94 |
| rgp1 | SPECMTS3 | 4932 | -21.72 |
| drs2 | SPECMTS3 | 4932 | -20.77 |
| rpn1 | SPECMTS3 | 4932 | -20.69 |
| bck1 | SPECMTS3 | 4932 | -18.88 |
Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.
Recorded target evidence and yeast matches
Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.
| Target | Source | Yeast ORF / orthologue |
|---|---|---|
| ALOX12 · Polyunsaturated fatty acid lipoxygenase ALOX12 | ChEMBL | No stored yeast mapping |
| ESR2 · Estrogen receptor beta | ChEMBL | No stored yeast mapping |
| groL · GroEL/GroES | ChEMBL | No stored yeast mapping |
| HSPD1 · HSP60/HSP10 | ChEMBL | No stored yeast mapping |
| KAT2A · Histone acetyltransferase KAT2A | ChEMBL | BDF2 YDL070W (ortholog_many2many); BDF1 YLR399C (ortholog_many2many) |
| KDM4E · Lysine-specific demethylase 4E | ChEMBL | YJR119C (ortholog_one2many) |
| MCL1 · Induced myeloid leukemia cell differentiation protein Mcl-1 | ChEMBL | No stored yeast mapping |
| MEN1 · Menin/Histone-lysine N-methyltransferase MLL | ChEMBL | No stored yeast mapping |
| NS1 · Nonstructural protein 1 | ChEMBL | No stored yeast mapping |
| POLB · DNA polymerase beta | ChEMBL | No stored yeast mapping |
| PYK · Pyruvate kinase | ChEMBL | No stored yeast mapping |
| Rorc · Nuclear receptor ROR-gamma | ChEMBL | No stored yeast mapping |
| AKR1B1 · Aldo-keto reductase family 1 member B1 | ChEMBL analogue | AAD3 YCR107W (ortholog_many2many); AAD4 YDL243C (ortholog_many2many); YPR1 YDR368W (ortholog_many2many); AAD10 YJR155W (ortholog_many2many); AAD14 YNL331C (ortholog_many2many); AAD15 YOL165C (ortholog_many2many); GCY1 YOR120W (ortholog_many2many) |
| ALOX12 · Polyunsaturated fatty acid lipoxygenase ALOX12 | ChEMBL analogue | No stored yeast mapping |
| ASPH · Aspartyl/asparaginyl beta-hydroxylase | ChEMBL analogue | No stored yeast mapping |
| BAD · Bcl2-associated agonist of cell death | ChEMBL analogue | No stored yeast mapping |
| BCL2 · Apoptosis regulator Bcl-2 | ChEMBL analogue | No stored yeast mapping |
| BCL2L1 · Bcl-2-like protein 1 | ChEMBL analogue | No stored yeast mapping |
| guaB · Inosine-5'-monophosphate dehydrogenase | ChEMBL analogue | No stored yeast mapping |
| LDHB · L-lactate dehydrogenase B chain | ChEMBL analogue | MDH3 YDL078C (ortholog_many2many); MDH1 YKL085W (ortholog_many2many) |
| lef · Lethal factor | ChEMBL analogue | No stored yeast mapping |
| MCL1 · Induced myeloid leukemia cell differentiation protein Mcl-1 | ChEMBL analogue | No stored yeast mapping |
| POLB · DNA polymerase beta | ChEMBL analogue | No stored yeast mapping |
Structural activity predictions and SONAR
Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.
SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.
Open the complete GOSSYPOL-ACETIC ACID COMPLEX research profile →Sources and provenance
Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.
Card snapshot: 2026-11-02. Linked interactive views may contain newer data.