CHEMGRID MOLECULE CARD

SURAMIN

SURAMIN in ChemGrid: 104 screened assays, 1 with significant responses. Explore chemical identifiers, strain activity and target evidence.

SPE01502032

Explore activity & SONAR

Chemical structure of SURAMIN — Stored molecular structure

104Screened assays

1Significant assay responses

9Source-labelled target records

Identity and chemistry

ChemGrid identifier: SPE01502032
Molecular formula: C51H34N6Na6O23S6
InChIKey: VAPNKLKDKUDFHK-UHFFFAOYSA-H
Libraries: SPECMTS3, Spectrum_ED
Other recorded names: Suramin Sodium

Stored SMILES

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)c1cc2c(ccc(NC(=O)c3ccc(C)c(NC(=O)c4cccc(NC(=O)Nc5cccc(c5)C(=O)Nc5cc(ccc5C)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c4)c3)c2c(c1)S([O-])(=O)=O)S([O-])(=O)=O

Matched external records: PubChem 8514

Chemical identifiers and library names are reproduced from ChemGrid records. Missing values are omitted.

Measured chemical–genetic activity

104 measurements across 104 distinct library–species–strain assays; 1 assays have at least one significant response (|Z| ≥ 4, p ≤ 0.001, excluding flagged outliers).

Responses are indirect screening phenotypes. They do not establish that a strain gene is a direct molecular target. Strains and timepoints are retained as recorded; these counts are not counts of unique ORFs.

Up to 12 strongest recorded single-strain responses by absolute Z-score
Strain	Library	Species identifier	Z-score
BY4741	Spectrum_ED	4932	4.22

Spectrum compound-combination identifiers are excluded from this short table. The interactive profile retains the full measurements.

Recorded target evidence and yeast matches

Source annotations are shown separately from SONAR hypotheses. Evidence type and identity matching can vary; consult the linked source and interactive evidence panel.

Target	Source	Yeast ORF / orthologue
BLM · RecQ-like DNA helicase BLM	ChEMBL	SGS1 YMR190C (ortholog_one2one)
Chrm1 · Muscarinic acetylcholine receptor M1	ChEMBL	No stored yeast mapping
HSD17B10 · 3-hydroxyacyl-CoA dehydrogenase type-2	ChEMBL	No stored yeast mapping
LMNA · Prelamin-A/C	ChEMBL	No stored yeast mapping
NFKB1 · Nuclear factor NF-kappa-B p105 subunit	ChEMBL	No stored yeast mapping
POLB · DNA polymerase beta	ChEMBL	No stored yeast mapping
PYK · Pyruvate kinase	ChEMBL	No stored yeast mapping
SIRT1 · NAD-dependent protein deacetylase sirtuin-1	ChEMBL	SIR2 YDL042C (ortholog_one2many); HST1 YOL068C (ortholog_one2many)
SIRT2 · NAD-dependent protein deacetylase sirtuin-2	ChEMBL	HST2 YPL015C (ortholog_one2one)

Structural activity predictions and SONAR

Stored structural activity predictions are available in the interactive profile, with assay-specific cutoffs and applicability-domain assessments.

SONAR ranks candidate targets through genetic and physical interaction evidence. Structural SONAR uses predicted strain responses; measured SONAR uses experimental responses. These are experimental hypotheses, not confirmed binding targets. Outside-domain predictions are treated as unknown.

Open the complete SURAMIN research profile →

Sources and provenance

Screening measurements: ChemGrid chemical-genetic datasets. Wildenhain et al., Cell Systems (2015). Target annotations: sources named in the evidence table. Structure and library metadata: stored ChemGrid catalogue records.

Card snapshot: 2026-11-02. Linked interactive views may contain newer data.